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1. (WO1991017159) 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017159 International Application No.: PCT/GB1991/000706
Publication Date: 14.11.1991 International Filing Date: 02.05.1991
IPC:
A61K 31/506 (2006.01) ,A61K 45/06 (2006.01) ,C07D 411/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
411
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
IAF BIOCHEM INTERNATIONAL INC. [CA/CA]; 10900 Hamon Street Montreal, Quebec H3M 3A1, CA (AllExceptUS)
COATES, Jonathan, Alan, Victor [GB/GB]; GB (UsOnly)
MUTTON, Ian, Martin [GB/GB]; GB (UsOnly)
PENN, Charles, Richard [GB/GB]; GB (UsOnly)
STORER, Richard [GB/GB]; GB (UsOnly)
WILLIAMSON, Christopher [GB/GB]; GB (UsOnly)
Inventors:
COATES, Jonathan, Alan, Victor; GB
MUTTON, Ian, Martin; GB
PENN, Charles, Richard; GB
STORER, Richard; GB
WILLIAMSON, Christopher; GB
Agent:
RITTER, Stephen, David; Mathys & Squire 10 Fleet Street London EC4Y 1AY, GB
Priority Data:
9009861.702.05.1990GB
Title (EN) 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES
(FR) ANALOGUES DE NUCLEOSIDES DE 1,3-OXATHIOLANE
Abstract:
(EN) (-)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulations thereof, methods for its preparation and its use as an antiviral agent are described.
(FR) L'invention décrit: (-)-4-amino-1-(2-hydroxyméthyle-1,3-oxathiolane-5-yl)-(1H)-pyrimidine-2-one, ses dérivés acceptables sur le plan pharmaceutique, ses formulations pharmaceutiques, procédés de préparation et son utilisation comme agent antiviral.
Designated States: AU, BG, CA, FI, HU, JP, KR, LK, NO, PL, RO, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI916165FI954183KG940209.1MD94-0298NO19920018SG46383
IL98025ZA1991/03293MA22144EP0625150EP1062950RU02099338
US6180639US20030004175US20050250950JPH05501117JP11080153 JP2000128787
CN1326743CA2059263CA2337748PT97520KR1019920702682AU1991077719
ID002.053MYPI 91000734GEP19991705BBG60679