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1. (WO1991017158) INTERMEDIATES IN THE FORMATION OF THE CALICHEAMICIN AND ESPERAMICIN OLIGOSACCHARIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017158 International Application No.: PCT/US1991/003090
Publication Date: 14.11.1991 International Filing Date: 06.05.1991
Chapter 2 Demand Filed: 27.11.1991
IPC:
C07D 263/24 (2006.01) ,C07D 309/30 (2006.01) ,C07D 491/04 (2006.01) ,C07D 493/04 (2006.01) ,C07D 521/00 (2006.01) ,C07F 7/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Oxygen atoms
20
attached in position 2
24
with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16
having one double bond between ring members or between a ring member and a non-ring member
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Oxygen atoms, e.g. delta-lactones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
521
Heterocyclic compounds containing unspecified hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
Applicants:
SCRIPPS CLINIC AND RESEARCH FOUNDATION [US/US]; 10666 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
NICOLAOU, Kyriacos, C.; US
GRONEBERG, Robert, D.; US
SCHREINER, Erwin, P.; US
STAHL, Wilhelm; US
Agent:
GAMSON, Edward, P.; Dressler, Goldsmith, Shore, Sutker & Milnamow, Ltd. 4700 Two Prudential Plaza 180 North Stetson Avenue Chicago, IL 60601 , US
Priority Data:
520,24507.05.1990US
695,25103.05.1991US
Title (EN) INTERMEDIATES IN THE FORMATION OF THE CALICHEAMICIN AND ESPERAMICIN OLIGOSACCHARIDES
(FR) INTERMEDIAIRES INTERVENANT DANS LA FORMATION DES OLIGOSACCHARIDES DE CALICHEAMICINE ET D'ESPERAMICINE
Abstract:
(EN) Intermediates useful in preparing the calicheamicin and esperamicin oligosaccharides, and particularly the sulfur- and O-substituted hydroxylamine-containing B ring of both oligosaccharides, are disclosed as are methods of making and using the same, including the preparation of chimeric antibiotics using the same.
(FR) Intermédiaires utiles dans la préparation des oligosaccharides de calichéamicine et d'espéramicine, et notamment le cycle B contenant de l'hydroxylamine à substitution de soufre et à substitution O des deux oligosaccharides, et leurs procédés de fabrication et d'utilisation consistant en la préparation d'antibiotiques chimériques les utilisant.
Designated States: AU, CA, FI, JP, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI925026NO19924280EP0530225JPH05507080CA2082152AU1991077941