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1. (WO1991017151) NEW PHARMACOLOGICALLY ACTIVE CATECHOL DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017151 International Application No.: PCT/FI1991/000124
Publication Date: 14.11.1991 International Filing Date: 26.04.1991
Chapter 2 Demand Filed: 21.11.1991
IPC:
C07D 233/96 (2006.01) ,C07D 239/40 (2006.01) ,C07D 239/54 (2006.01) ,C07D 239/60 (2006.01) ,C07D 239/62 (2006.01) ,C07D 263/46 (2006.01) ,C07D 277/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
96
having three double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
38
One sulfur atom
40
as doubly bound sulfur atom or as unsubstituted mercapto radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
52
Two oxygen atoms
54
as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
60
Three or more oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
60
Three or more oxygen or sulfur atoms
62
Barbituric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
30
having two or three double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
46
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
Applicants:
ORION-YHTYMÄ OY [FI/FI]; Orionintie 1 SF-02100 Espoo, FI (AllExceptUS)
BÄCKSTRÖM, Reijo [FI/FI]; FI (UsOnly)
HONKANEN, Erkki [FI/FI]; FI (UsOnly)
LINDÉN, Inge-Britt [FI/FI]; FI (UsOnly)
NISSINEN, Erkki [FI/FI]; FI (UsOnly)
PIPPURI, Aino [FI/FI]; FI (UsOnly)
POHTO, Pentti [FI/FI]; FI (UsOnly)
KORKOLAINEN, Tapio [FI/FI]; FI (UsOnly)
Inventors:
BÄCKSTRÖM, Reijo; FI
HONKANEN, Erkki; FI
LINDÉN, Inge-Britt; FI
NISSINEN, Erkki; FI
PIPPURI, Aino; FI
POHTO, Pentti; FI
KORKOLAINEN, Tapio; FI
Agent:
ORION CORPORATION; Orion-Farmos Pharmaceuticals Patent Department P.O. Box 65 FIN-02101 Espoo, FI
Priority Data:
9009565.427.04.1990GB
9101563.624.01.1991GB
Title (EN) NEW PHARMACOLOGICALLY ACTIVE CATECHOL DERIVATIVES
(FR) NOUVEAUX DERIVES DE PYROCATECHINE A ACTIVITE PHARMACOLOGIQUE
Abstract:
(EN) Compounds of formula (I), wherein R1 is an electronegative substituent such as nitro, halogeno or cyano group and R2 is a group selected from (Ia) and (Ib), wherein R is hydrogen, or an alkyl, cycloalkyl, aralkyl or aryl group, wherein X1, X2, Y and Z are independently oxygen, sulfur of NR, wherein R may be as defined above and pharmaceutically acceptable esters and salts thereof are useful in the prevention or treatment of tissue damage induced by lipid peroxidation.
(FR) Les composés correspondant à la formule (I), dans laquelle R1 est un substituant électronégatif tel qu'un groupe nitro, halogéno ou cyano, et R2 est une groupe sélectionné parmi (Ia) et (Ib), où R est hydrogène ou un groupe alkyle, cycloalkyle, aralkyle ou aryle, où X1, X2, Y et Z sont, indépendamment les uns des autres, oxygène, soufre de NR, où R peut être tel que ci-dessus, et leurs esters et sels pharmaceutiquement acceptables, sont utiles à la prévention ou au traitement des lésions tissulaires dues à la peroxydation lipidique.
Designated States: AT, AU, CA, CH, DE, DK, ES, FI, GB, HU, KR, LU, NL, NO, PL, SE, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI924838NO19924132EP0526598RU02096407US5362733CA2080917
KR1019930700468AU1991077618