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1. (WO1991017149) 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1991/017149 International Application No.: PCT/US1991/002889
Publication Date: 14.11.1991 International Filing Date: 26.04.1991
Chapter 2 Demand Filed: 01.11.1991
IPC:
C07C 45/46 (2006.01) ,C07C 45/56 (2006.01) ,C07C 45/68 (2006.01) ,C07C 45/71 (2006.01) ,C07C 59/66 (2006.01) ,C07C 59/68 (2006.01) ,C07C 69/76 (2006.01) ,C07C 69/94 (2006.01) ,C07C 323/56 (2006.01) ,C07D 257/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
45
by condensation
46
Friedel-Crafts reactions
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
56
from heterocyclic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
67
by isomerisation; by change of size of the carbon skeleton
68
by increase in the number of carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
67
by isomerisation; by change of size of the carbon skeleton
68
by increase in the number of carbon atoms
70
by reaction with functional groups containing oxygen only in singly bound form
71
being hydroxy groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
58
containing ether groups, groups, groups, or groups
64
containing six-membered aromatic rings
66
the non-carboxylic part of the ether containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
58
containing ether groups, groups, groups, or groups
64
containing six-membered aromatic rings
66
the non-carboxylic part of the ether containing six-membered aromatic rings
68
the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
76
Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
76
Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
94
of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50
containing thio groups and carboxyl groups bound to the same carbon skeleton
51
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
56
the carbon skeleton containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
257
Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
04
Five-membered rings
Applicants:
FRAZEE, James, Simpson [US/US]; US (UsOnly)
GLEASON, John, Gerald [CA/US]; US (UsOnly)
HALL, Ralph, Floyd [US/US]; US (UsOnly)
UZINSKAS, Irene, Nijole [US/US]; US (UsOnly)
SMITHKLINE BEECHAM CORPORATION [US/US]; Corporate Patents-U.S., UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406, US (AllExceptUS)
Inventors:
FRAZEE, James, Simpson; US
GLEASON, John, Gerald; US
HALL, Ralph, Floyd; US
UZINSKAS, Irene, Nijole; US
Agent:
KANAGY, James, M. ; Smithkline Beecham Corporation Corporate Patents - U.S. UW2220 709 Swedeland Road P.O. Box 1538 King of Prussia, PA 19406-0939, US
Priority Data:
518,58301.05.1990US
Title (EN) 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS
(FR) ANTAGONISTES DE LEUCOTRIENE A ACIDE ALCANOIQUE SUBSTITUE OXY OU NAPHTYLE-3-CARBOXYALKYLTHIO-3
Abstract:
(EN) This invention relates to alkanoic acid compounds having a naphthyl ring and thio substituents which are useful as leukotriene antagonists.
(FR) Composés d'acide alcanoïque possédant un anneau naphtyle et des substituants thio utiles en tant qu'antagonistes de leucotriène.
Designated States: AU, CA, JP, KR, US
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)