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1. (WO1991017147) NEW URACIL DERIVATIVES HAVING AN ANTI-TUMOUR ACTIVITY AND RELATED COMPOUNDS (N-1 DERIVATIVES OF 5-SUBSTITUTED-URACILE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017147 International Application No.: PCT/ES1991/000028
Publication Date: 14.11.1991 International Filing Date: 06.05.1991
IPC:
C07D 239/54 (2006.01) ,C07D 239/553 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
52
Two oxygen atoms
54
as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
52
Two oxygen atoms
54
as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
545
with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
553
with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Applicants:
UNIVERSIDAD DE GRANADA [ES/ES]; Cuesta del Hospicio E-18071 Granada, ES (AllExceptUS)
ESPINOSA UBEDA, Antonio [ES/ES]; ES (UsOnly)
GALLO MEZO, Miguel, Angel [ES/ES]; ES (UsOnly)
CAMPOS ROSA, Joaquín [ES/ES]; ES (UsOnly)
PINEDA DE LAS INFANTAS Y VILLATORO, María, José [ES/ES]; ES (UsOnly)
ENTRENA GUADIX, Antonio [ES/ES]; ES (UsOnly)
CAMACHO QUESADA, Encarnación [ES/ES]; ES (UsOnly)
DOMINGUEZ SEGLAR, José, Francisco [ES/ES]; ES (UsOnly)
Inventors:
ESPINOSA UBEDA, Antonio; ES
GALLO MEZO, Miguel, Angel; ES
CAMPOS ROSA, Joaquín; ES
PINEDA DE LAS INFANTAS Y VILLATORO, María, José; ES
ENTRENA GUADIX, Antonio; ES
CAMACHO QUESADA, Encarnación; ES
DOMINGUEZ SEGLAR, José, Francisco; ES
Agent:
MONTELLANO DELGADO, María, Angustias; Cuesta del Hospicio E-18071 Granada, ES
Priority Data:
P 900127107.05.1990ES
Title (EN) NEW URACIL DERIVATIVES HAVING AN ANTI-TUMOUR ACTIVITY AND RELATED COMPOUNDS (N-1 DERIVATIVES OF 5-SUBSTITUTED-URACILE
(ES) NUEVOS DERIVADOS DE URACILO CON ACTIVIDAD ANTITUMORAL Y COMPUESTOS REFERIBLES (N-1-DERIVADOS DE URACILOS-5-SUSTITUIDOS)
(FR) NOUVEAUX DERIVES D'URACILE AVEC ACTIVITE ANTI-TUMORALE ET COMPOSES APPARENTES (N-1 DERIVES D'URACILES-5 SUBSTITUES)
Abstract:
(EN) The present invention relates to new chemical compounds having interesting and anti-tumor properties and low acute toxicity and its production according to the general reaction (I). In order to produce compounds wherein X = SO, a starting compound wherein X = S is used and is then subjected to oxidation with sodic periodate.
(ES) El presente invento está relacionado con nuevos compuestos químicos con interesantes propiedades antitumorales y baja toxicidad aguda y su obtención según la reacción general (I). Para la obtención de compuestos en los que X=SO se parte de aquel en que X=S y se somete a oxidación con peryodato sódico.
(FR) L'invention concerne de nouveaux composés chimiques ayant d'intéressantes propriétés anti-tumorales et une faible toxicité aiguë ainsi que leur obtention selon la réaction générale (I). Pour l'obtention de composés dans lesquels X = SO, on part du composé dans lequel X = S et on le soumet à une oxydation avec un periodate sodique.
Designated States: BR, CA, JP, NO, SE, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)