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1. (WO1991017138) PROCESS FOR PREPARING 3,4-DIFLUOROANILINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017138 International Application No.: PCT/US1991/002540
Publication Date: 14.11.1991 International Filing Date: 12.04.1991
Chapter 2 Demand Filed: 19.09.1991
IPC:
C07C 209/74 (2006.01) ,C07C 239/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
68
from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
74
by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
239
Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
08
Hydroxylamino compounds or their ethers or esters
10
having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of unsubstituted hydrocarbon radicals or of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017-5755, US (AllExceptUS)
BRAISH, Tamim, F. [LB/US]; US (UsOnly)
Inventors:
BRAISH, Tamim, F.; US
Agent:
RICHARDSON, Peter, C. ; Pfizer Inc. 235 East 42nd Street New York, NY 10017, US
Priority Data:
517,26401.05.1990US
Title (EN) PROCESS FOR PREPARING 3,4-DIFLUOROANILINE
(FR) PROCEDE DE PREPARATION DE DIFLUOROANILINE-3,4
Abstract:
(EN) A process for preparing 3,4-difluoroaniline comprising reacting 1-hydroxylamine-3-fluorobenzene with anhydrous hydrogen fluoride in the absence of oxygen. This compound is useful as a starting material for preparation of quinolone antibacterials. 3-Fluoro-1-hydroxylamine may be prepared by hydrogenating 3-fluoro-1-nitrobenzene.
(FR) Procédé de préparation de difluoroaniline-3,4 consistant à faire réagir le hydroxylamine-1-fluorobenzène-3 avec le fluorure d'hydrogène anhydre en l'absence d'oxygène. Ce composé est utile en tant que produit de départ pour la préparation des produits antibactériens à quinolone. On peut préparer le fluoro-3-hydroxylamine-1 par l'hydrogénation du fluoro-3-nitrobenzène-1.
Designated States: CA, FI, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI924931EP0527154JPH05502036CA2080596PT97530