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1. (WO1991016931) CLOT IMAGING AGENTS AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016931 International Application No.: PCT/US1991/003212
Publication Date: 14.11.1991 International Filing Date: 09.05.1991
Chapter 2 Demand Filed: 06.12.1991
IPC:
A61K 38/00 (2006.01) ,A61K 49/14 (2006.01) ,A61K 51/08 (2006.01) ,C12N 9/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
14
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
Applicants:
ZYMOGENETICS, INC. [US/US]; 4225 Roosevelt Way, N.E. Seattle, WA 98105, US
Inventors:
BISHOP, Paul, D.; US
Agent:
MAKI, David, J. ; Seed and Berry 6300 Columbia Center Seattle, WA 98104-7092, US
BROWN, John, D.; Forrester & Boehmert Widenmayerstrasse 4 D-8000 München 22, DE
Priority Data:
521,80510.05.1990US
525,55618.05.1990US
Title (EN) CLOT IMAGING AGENTS AND USE THEREOF
(FR) AGENTS D'IMAGERIE DE CAiLLOTS ET LEUR EMPLOI
Abstract:
(EN) Methods and compositions for detecting blood clots in a patient are disclosed. Factor XIII or a factor XIII derivative is coupled to a substance capable of detection, such as a radioisotope or paramagnetic compound, and combined with a physiologically acceptable carrier or diluent. The resulting composition is administered to a patient to detect venous or arterial thrombosis. Also disclosed are novel factor XIII derivatives, including null mutants of factor XIII zymogen and factor XIIIa.
(FR) Procédés et compositions de détection de caillots sanguins chez un patient. On couple le facteur XIII ou un dérivé du facteur XIII à une substance capable d'une détection telle qu'un radioisotope ou un composé paramagnétique, et on les combine à un support ou à un diluant physiologiquement acceptable. On administre la composition obtenue à un patient afin de détecter une trombose veineuse ou artérielle. L'invention concerne également de nouveaux dérivés du facteur XIII parmi lesquels des mutants nuls de zymogène du facteur XIII et de facteur XIIIa.
Designated States: AU, CA, FI, HU, JP, NO, PL
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991079820