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1. (WO1991016928) HUMANIZED CHIMERIC ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016928 International Application No.: PCT/US1991/002946
Publication Date: 14.11.1991 International Filing Date: 29.04.1991
Chapter 2 Demand Filed: 05.11.1991
IPC:
A61K 38/00 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
CELLTECH LIMITED [GB/GB]; 216 Bath Road Slough Berkshire SL1 4EN, GB (AllExceptUS)
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. [US/US]; 90 East Ridge P.O. Box 368 Ridgefield, CT 06877, US (AllExceptUS)
ADAIR, John, Robert [GB/GB]; GB (UsOnly)
ROBINSON, Martyn, Kim [GB/GB]; GB (UsOnly)
BRIGHT, Susan, Margaret [GB/GB]; GB (UsOnly)
ROTHLEIN, Robert, A. [US/US]; US (UsOnly)
Inventors:
ADAIR, John, Robert; GB
ROBINSON, Martyn, Kim; GB
BRIGHT, Susan, Margaret; GB
ROTHLEIN, Robert, A.; US
Agent:
FOX, Samuel, L. ; Sterne, Kessler, Goldstein & Fox 1225 Connecticut Avenue, N.W. Suite 300 Washington, DC 20036, US
Priority Data:
9009548.027.04.1990GB
Title (EN) HUMANIZED CHIMERIC ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USE
(FR) ANTICORPS ANTI-MOLECULE 1 d'ADHERENCE INTERCELLULAIRE CHIMERIQUE ADAPTES AU MODELE HUMAIN, PROCEDE DE PREPARATION ET D'UTILISATION
Abstract:
(EN) The present invention discloses humanized chimeric antibodies which are capable of binding to the intercellular adhesion molecule ICAM-1. Specifically, disclosed are humanized anti-ICAM-1 antibodies of the IgG1, IgG2, and IgG4 subtype. These antibodies are useful in treating specific and non-specific inflammation, rhinoviral infection, HIV infection, the dissemination of HIV infected cells, and asthma. In addition, the humanized antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation and infection and tumors expressing ICAM-1.
(FR) Anticorps chimériques adaptés au modèle humain capables de se lier à la molécule d'adhérence intercellulaire ICAM-1. Spécifiquement, l'invention concerne des anticorps anti-ICAM-1 adaptés au modèle humain des sous-types de IgG1, IgG2, et IgG4. Ces anticorps sont utiles dans le traitement d'inflammations spécifiques et non spécifiques, d'infections rhinovirales, d'infections par VIH, de la dissémination de cellules contaminées par VIH, et de l'asthme. De plus, les anticorps adaptés au modèle humain peuvent être utiles dans des procédés de diagnostic et de localisation de sites d'inflammation et d'infection ainsi que de tumeurs exprimant la ICAM-1.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, PL, RO, SD, SE, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI924819NO19924088NO19984136ES2118084EP0528931JPH05507406
CA2081479DE000069129743AU1991078603DK0528931