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1. (WO1991016922) ANALOGS OF GLYCOPROTEIN HORMONES HAVING ALTERED IMMUNOLOGICAL CHARACTERISTICS, EFFICACY AND/OR RECEPTOR SPECIFICITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016922 International Application No.: PCT/US1991/003162
Publication Date: 14.11.1991 International Filing Date: 07.05.1991
Chapter 2 Demand Filed: 04.12.1991
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/145 (2006.01) ,C07K 14/575 (2006.01) ,C07K 14/59 (2006.01) ,C07K 16/26 (2006.01) ,C12N 15/85 (2006.01) ,C12N 15/89 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
145
Rhabdoviridae, e.g. rabies virus, Duvenhage virus, Mokda virus, vesicular stomatitis virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
59
Follicle-stimulating hormone (FSH); Chorionic gonadotropins, e.g. HCG; Luteinising hormone (LH); Thyroid-stimulating hormone (TSH)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
26
against hormones
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
89
using micro-injection
Applicants:
UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY [US/US]; 110 Administration Complex 30 Bergen Street University Heights Newark, NJ 07101-3000, US (AllExceptUS)
CAMPBELL, Robert, K. [US/US]; US (UsOnly)
MOYLE, William, R. [US/US]; US (UsOnly)
Inventors:
CAMPBELL, Robert, K.; US
MOYLE, William, R.; US
Agent:
MUCCINO, Richard, R.; 758 Springfield Avenue Summit, NJ 07901, US
Priority Data:
520,70308.05.1990US
Title (EN) ANALOGS OF GLYCOPROTEIN HORMONES HAVING ALTERED IMMUNOLOGICAL CHARACTERISTICS, EFFICACY AND/OR RECEPTOR SPECIFICITY
(FR) ANALOGUES D'HORMONES GLYCOPROTEIQUES AYANT DES CARACTERISTIQUES IMMUNOLOGIQUES, UNE EFFICACITE ET/OU UNE SPECIFICITE DE RECEPTION MODIFIEES
Abstract:
(EN) The invention relates to modified chorionic gonadotropin (CG) $i(alpha), $i(beta)-heterodimeric polypeptides comprising a glycoprotein hormone $i(alpha)-subunit polypeptide and a non-naturally occurring $i(beta)-subunit polypeptide. The modifications in the $i(beta)-subunit polypeptide involve the deletion, addition, or substitution of one or more amino acid residues. The modified heterodimeric polypeptides of the invention have different properties compared to native hCG. Certain $i(alpha), $i(beta)-heterodimeric polypeptides bind to LH and FSH receptors and stimulate steroidogenesis in testicular and ovarian cells. Other $i(alpha), $i(beta)-heterodimeric polypeptides bind to LH receptors but have lower efficacy than hCG to stimulate steroidogenesis in testicular and ovarian cells.
(FR) Polypeptides hétérodimères $i(alpha), $i(bêta) modifiés de gonadotropine chorionique (GC) comprenant un polypeptide de sous-unité $i(alpha) d'hormone de glycoprotéine et une sous-unité $i(bêta) de polypeptide n'existant pas naturellement. Les modifications dans les polypeptide de sous-unité $i(bêta) sont la suppression, l'adjonction, ou la substitution d'un ou plusieurs restes d'acides aminés. Les polypeptides hétérodimères modifiés selon la présente invention ont des propriétés différentes comparées à celles de la CGh native. Certains polypeptides hétérodimères $i(alpha), $i(bêta) se lient à des récepteurs de LH et de FSH et stimulent la stéroidogenèse des cellules ovariennes et testiculaires. D'autres polypeptides hétérodimères $i(alpha), $i(bêta) se lient à des récepteurs de LH mais sont moins efficaces que la GCh pour stimuler la stéroidogenèse des cellules ovariennes et testiculaires.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0531407CA2082424