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1. (WO1991016902) INHIBITION OF INFLUENZA VIRUS REPLICATION BY OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016902 International Application No.: PCT/US1991/002932
Publication Date: 14.11.1991 International Filing Date: 29.04.1991
Chapter 2 Demand Filed: 18.11.1991
IPC:
C07H 21/00 (2006.01) ,C12N 15/11 (2006.01) ,C12Q 1/70 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
HYBRIDON, INC. [US/US]; One Innovation Drive Massachusetts Biotechnology Research Park Worcester, MA 01605, US
Inventors:
AGRAWAL, Sudhir; US
LEITER, Josef, M., E.; US
PALESE, Peter; US
ZAMECNIK, Paul, C.; US
Agent:
KEOWN, Wayne, A.; Allegretti & Witcoff, Ltd. Ten South Wacker Drive Chicago, IL 60606, US
Priority Data:
516,27530.04.1990US
Title (EN) INHIBITION OF INFLUENZA VIRUS REPLICATION BY OLIGONUCLEOTIDES
(FR) INHIBITION DE LA REPLICATION DU VIRUS DE LA GRIPPE A L'AIDE D'OLIGONUCLEOTIDES
Abstract:
(EN) A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hybridize to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides.
(FR) Procédé d'inhibition de la réplication du virus de la grippe par l'activité d'oligonucléotides (oligodésoxynucléotides) ou oligoribonucléotides) naturels (non modifiés) ou modifiés, lesquels s'hybrident à une région sélectionnée de l'ARN du virus de la grippe et perturbent sa capacité de servir de gabarit dans la synthèse de produits codés. L'invention concerne également des oligonucléotides (non modifiés ou modifiés) présentant une activité antivirale contre le virus de la grippe du fait de leur capacité de s'hybrider à une région sélectionnée d'ARN du virus de la grippe et d'inhiber sa capacité de servir de gabarit dans la synthèse de produits codés, ainsi que des compositions comprenant les oligonucléotides.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0527906JPH05506997CA2081777