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1. (WO1991016898) ANTI-FUNGAL BILE ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016898 International Application No.: PCT/GB1991/000710
Publication Date: 14.11.1991 International Filing Date: 03.05.1991
Chapter 2 Demand Filed: 26.11.1991
IPC:
A61K 31/575 (2006.01) ,C07J 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
9
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Applicants:
BRITISH TECHNOLOGY GROUP LTD [GB/GB]; 101 Newington Causeway London SE1 6BU, GB (AllExceptUS)
MARPLES, Brian, Arthur [GB/GB]; GB (UsOnly)
STRETTON, Reginald, John [GB/GB]; GB (UsOnly)
Inventors:
MARPLES, Brian, Arthur; GB
STRETTON, Reginald, John; GB
Agent:
PERCY, Richard, Keith; Patents Dept. British Technology Group Limited 101 Newington Causeway London SE1 6BU, GB
Priority Data:
9010087.604.05.1990GB
Title (EN) ANTI-FUNGAL BILE ACID DERIVATIVES
(FR) DERIVES D'ACIDE BILIAIRE A ACTION MYCOSTATIQUE
Abstract:
(EN) Compounds of general formula (7), wherein X is a hydrogen atom or a hydroxyl group, Y is a hydrogen atom or a hydroxyl group and at least one of X and Y is a hydroxyl group and Z is a hydroxyl group or a methylol (-CH2OH) group, have anti-fungal activity, especially against organisms selected from $i(Candida) spp. and the athlete's foot/ringworm organisms $i(Trichophyton mentagrophytes) and $i(Microsporum audonii). Compounds in which Z is a methylol (-CH2OH) group are claimed $i(perse).
(FR) Composés correspondant à la formule générale (7): dans laquelle X représente un atome d'hydrogène ou un groupe hydroxyle, Y représente un atome d'hydrogène ou un groupe hydroxyle et, au moins soit X, soit Y représente un groupe hydroxyle et Z représente un groupe hydroxyle ou un groupe méthylol (-CH2OH), qui possèdent une eficacité anti-mycosique, particulièrement contre des organismes sélectionnés à partir de $i(Candida) spp. et des organismes impliqués dans la teigne et l'épidermomycose du pied, tels que $i(Tricophyton mentagrophytes) et $i(Microsporum audonii). Les composés dans lesquels Z représente un groupe méthylol (-CH2OH), font l'objet d'une revendication spécifique.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0527832US5304551JPH05508392CA2081468GB2243550