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1. (WO1991016897) METHOD, COMPOSITIONS, AND COMPOUNDS FOR MODULATING BRAIN EXCITABILITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016897 International Application No.: PCT/US1991/002699
Publication Date: 14.11.1991 International Filing Date: 19.04.1991
Chapter 2 Demand Filed: 07.10.1991
IPC:
A61K 31/57 (2006.01) ,C07J 1/00 (2006.01) ,C07J 5/00 (2006.01) ,C07J 7/00 (2006.01) ,C07J 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
1
Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
5
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
7
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
43
Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
Applicants:
GEE, Kelvin, Wellman [US/US]; US
BOLGER, Michael, Bruce [US/US]; US
Inventors:
GEE, Kelvin, Wellman; US
BOLGER, Michael, Bruce; US
Agent:
SCHNEIDER, Carol, A. ; 611 West Sixth Street 34th Floor Los Angeles, CA 90017, US
Priority Data:
521,72410.05.1990US
Title (EN) METHOD, COMPOSITIONS, AND COMPOUNDS FOR MODULATING BRAIN EXCITABILITY
(FR) PROCEDE, COMPOSITIONS ET COMPOSES DE MODULATION DE L'EXCITABILITE CEREBRALE
Abstract:
(EN) Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionophore (GBR) complex.
(FR) Procédé, compositions et composés de modulation de l'excitabilité cérébrale, servant à soulager le stress, l'angoisse et les crises d'épilepsie à l'aide de certains dérivés stéroïdiens agissant au niveau d'un site nouvellement identifié situé dans le complexe ionophore à chlorure récepteur et à acide gamma-aminobutyrique/benzodiazépine (complexe GBR).
Designated States: AU, CA, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19924238EP0527962JPH06505958CA2082501KR1019930700114AU1991077714