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1. (WO1991016883) CONTROLLED RELEASE VEHICLE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016883 International Application No.: PCT/US1991/003144
Publication Date: 14.11.1991 International Filing Date: 07.05.1991
Chapter 2 Demand Filed: 09.12.1991
IPC:
A61F 13/15 (2006.01) ,A61K 9/16 (2006.01) ,A61K 9/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
13
Bandages or dressings; Absorbent pads
15
Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
Applicants:
MICRO VESICULAR SYSTEMS, INC. [US/US]; 20 Cotton Road Nashua, NH 03063, US
Inventors:
CHANG, An-Cheng; US
WALLACH, Donald, F., H.; US
Agent:
LOREN, Ralph, A. ; Lahive & Cockfield 60 State Street Boston, MA 02109, US
Priority Data:
521,08609.05.1990US
Title (EN) CONTROLLED RELEASE VEHICLE
(FR) VEHICULE A LIBERATION REGULEE
Abstract:
(EN) A new controlled release vehicle which acts by breakdown of the entrapping material upon hydration has been developed. The preferred release vehicle is made of a carboxylated cellulose, e.g., carboxymethylcellulose, which is treated with a cross-linking agent such as aluminum ions and, preferably, a hydrophobicity agent such as acetic acid. The vehicle is broken down by a release agent, e.g., cellulase, which may be coated on the vehicle together with a coating agent, e.g., hydroxypropylcellulose. The vehicle is dried, entrapping the molecule to be entrapped, e.g., an enzyme, and hydration activates the cellulase which breaks down the carboxymethylcellulose, releasing the entrapped molecule.
(FR) On a mis au point un nouveau véhicule à libération régulée qui agit par dégradation du matériau enveloppant lorsqu'on l'hydrate. Le véhicule à libération préféré est réalisé en cellulose carboxylée, par exemple, de la carboxyméthylcellulose, que l'on traite avec un agent réticulant tels que des ions aluminium et, de préférence, avec un agent d'hydrophobicité tel que de l'acide acétique. Le véhicule est décomposé par un agent de séparation, par exemple, de la cellulase, qui peut être enrobé sur le véhicule conjointement avec un agent d'enduction, par exemple. de l'hydroxypropylcellulose. Le véhicule est séché, enfermant ainsi la molécule devant être enfermée, par exemple, une enzyme, et l'hydratation active la cellulase qui décompoose la carboxyméthylcellulose, libérant ainsi la molécule enfermée.
Designated States: AU, BR, CA, HU, JP, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0527946CA2082496AU1991079812