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1. (WO1991016819) METHOD AND COMPOSITION FOR TREATMENT OF CENTRAL NERVOUS SYSTEMS DISEASE STATES ASSOCIATED WITH ABNORMAL AMYLOID BETA PROTEIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/016819 International Application No.: PCT/US1991/001898
Publication Date: 14.11.1991 International Filing Date: 26.03.1991
Chapter 2 Demand Filed: 20.11.1991
IPC:
A61K 38/17 (2006.01) ,A61K 39/145 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
Applicants:
MOLECULAR RX., INC. [US/US]; 2522 Refuge Road Pendleton, SC 29670, US
Inventors:
KLINE, Ellis, L.; US
MCMICHAEL, John; US
Agent:
WEGNER, Harold, C. ; Wegner, Cantor, Mueller & Player 1233 20th Street, N.W. Suite 300 P.O. Box 18218 Washington, DC 20036-8218, US
Priority Data:
514,02127.04.1990US
598,38316.10.1990US
Title (EN) METHOD AND COMPOSITION FOR TREATMENT OF CENTRAL NERVOUS SYSTEMS DISEASE STATES ASSOCIATED WITH ABNORMAL AMYLOID BETA PROTEIN
(FR) PROCEDE ET COMPOSITION SERVANT A TRAITER DES ETATS PATHOLOGIQUES DU SYSTEME NERVEUX CENTRAL ASSOCIES A LA PROTEINE BETA AMYLOIDE ANORMALE
Abstract:
(EN) A method and composition are provided for alleviation of disease states associated with the abnormal accumulation and/or molecular organization of amyloid beta protein, such as manifested in Alzheimer's disease and other CNS amyloid disorders. The invention comprises the administration of a low level of amyloid beta protein, or a derivative thereof, which slows or reverses neuronal loss or function.
(FR) Procédé et composition servant à atténuer des états pathologiques associés à l'accumulation anormale et/ou à l'organisation de la protéine bêta amyloïde, tels que ceux qui se manifestent dans la maladie d'Alzheimer et dans d'autres troubles amyloïdes du système nerveux central L'invention comprend l'administration d'un faible niveau de protéine bêta amyloïde ou de dérivés de cette protéine, qui ralentit ou qui inverse la perte ou la fonction neuronale.
Designated States: CA, JP, KR
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0526511JP2980677JPH06502387CA2081482