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1. WO1991016683 - SYSTEM AND METHOD FOR DETERMINING THREE-DIMENSIONAL STRUCTURES OF PROTEINS

Publication Number WO/1991/016683
Publication Date 31.10.1991
International Application No. PCT/US1991/002786
International Filing Date 23.04.1991
IPC
C07K 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G06F 17/50 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
17Digital computing or data processing equipment or methods, specially adapted for specific functions
50Computer-aided design
CPC
C07K 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G16B 15/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
15ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Applicants
  • SCRIPPS CLINIC AND RESEARCH FOUNDATION [US]/[US]
Inventors
  • SKOLNICK, Jeffrey
Agents
  • GAMSON, Edward, P.
Priority Data
513,91824.04.1990US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEM AND METHOD FOR DETERMINING THREE-DIMENSIONAL STRUCTURES OF PROTEINS
(FR) SYSTEME ET PROCEDE SERVANT A DETERMINER LES STRUCTURES TRIDIMENSIONNELLES DE PROTEINES
Abstract
(EN)
The system comprises an input means (57) such as a keyboard for specifying (entering) selected amino acid sequences and other data such as temperature and fold preferences, a RAM (random access memory) (59) for storing such data, a ROM (read-only memory) (61) with a stored program, a CRT (cathode ray tube) (63) display unit and/or printer (65) an optional auxiliary disc storage device (67) for storage of relevant data bases, and a microprocessor (69) for processing the entered data, for simulating, under control of the stored program, the folding of the protein from its unfolded state to its folded (tertiary) state, and for displaying via the display unit (or printer) tertiary conformations of the protein in three dimensions.
(FR)
Le système comprend un dispositif d'entrée (57), tel qu'un clavier, pour spécifier (introduire) des séquences d'amino-acides choisies et d'autres données, telles que la température et les préférences de pli, une mémoire à accès sélectif (RAM) (59) pour enregistrer de telles données, une mémoire fixe (ROM) (61) avec un programme enregistré, un terminal à écran cathodique (63) et/ou une imprimante (65), sur option, un dispositif de mémoire à disques auxiliaire (67) pour l'enregistrement de bases de données pertinentes et un microprocesseur (69) pour traiter les données introduites, pour simuler, sur commande du programme enregistré, le pliage de la protéine, depuis son état déplié jusqu'à son état plié (tertiaire) et pour présenter, au moyen d'une unité d'affichage (ou d'une imprimante), les conformations tertiaires de la protéine en trois dimensions.
Also published as
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