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1. WO1991012339 - ALLELIC ASSOCIATION OF THE HUMAN DOPAMINE (D¿2?) RECEPTOR GENE IN COMPULSIVE DISORDERS SUCH AS ALCOHOLISM

Publication Number WO/1991/012339
Publication Date 22.08.1991
International Application No. PCT/US1991/000855
International Filing Date 07.02.1991
Chapter 2 Demand Filed 28.08.1991
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]/[US] (AllExceptUS)
  • REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • NOBLE, E., P. [US]/[US] (UsOnly)
  • BLUM, Kenneth, L. [US]/[US] (UsOnly)
  • SHERIDAN, Peter, J. [US]/[US] (UsOnly)
Inventors
  • NOBLE, E., P.
  • BLUM, Kenneth, L.
  • SHERIDAN, Peter, J.
Agents
  • HODGINS, Daniel, S.
  • Grünecker, Kinkeldey, Stockmair & Partner
Priority Data
477,05707.02.1990US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ALLELIC ASSOCIATION OF THE HUMAN DOPAMINE (D2) RECEPTOR GENE IN COMPULSIVE DISORDERS SUCH AS ALCOHOLISM
(FR) ASSOCIATION ALLELOMORPHE DU GENE RECEPTEUR DE DOPAMINE (D2) HUMAINE DANS DES TROUBLES COMPULSIFS TELS QUE L'ALCOOLISME
Abstract
(EN)
In an important embodiment, the present invention concerns a method for diagnosing compulsive disease predisposition of an individual. The method comprises initially obtaining a DNA sample of said individual and then determining the presence or absence of a particular human D2 receptor gene allele in said sample. Detection of said allele in the sample is indicative of predilection to compulsive disease. A most preferred embodiment is to detect a susceptibility to alcoholism, particularly because said allele has been found to be present in a majority of clinically diagnosed alcoholics. The human D2 receptor gene A1 allele is most preferably detected in said sample.
(FR)
Dans un mode de réalisation important, l'invention concerne un procédé de diagnostic de la prédisposition d'un individu à des maladies compulsives. Le procédé consiste initialement à prélever un échantillon d'ADN sur ledit individu, puis à déterminer la présence ou l'absence, dans ledit échantillon, d'un gène allèle récepteur de D2 humaine particulier. La détection dudit allèle dans l'échantillon indique la prédisposition à des maladies compulsives. Un mode de réalisation particulièrement préféré consiste à détecter la susceptibilité de devenir alcoolique, notamment puisque l'on a découvert la présence dudit allèle chez une majorité d'alcooliques présentant des symptômes cliniques. On détecte, de préférence dans ledit échantillon, le gène A1 allèle récepteur de D2 humaine.
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