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1. (WO1991009970) A REMOVABLE MULTI-WELL CHAMBER DEVICE AND METHOD FOR INCUBATION OF CULTURED CELLS WITH SMALL VOLUMES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1991/009970 International Application No.: PCT/US1990/007545
Publication Date: 11.07.1991 International Filing Date: 19.12.1990
IPC:
B01L 3/00 (2006.01) ,C12M 1/20 (2006.01) ,C12M 3/00 (2006.01) ,G01N 33/53 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
16
containing, or adapted to contain, solid media
18
Multiple fields or compartments
20
Horizontal planar fields
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
WILLINGHAM, Mark, C. [US/US]; US
PASTAN, Ira [US/US]; US
Inventors:
WILLINGHAM, Mark, C.; US
PASTAN, Ira; US
Agent:
KESSLER, Edward, J. ; Sterne, Kessler, Goldstein & Fox 1225 Connecticut Avenue NW Suite 300 Washington, DC 20036, US
Priority Data:
455,13822.12.1989US
Title (EN) A REMOVABLE MULTI-WELL CHAMBER DEVICE AND METHOD FOR INCUBATION OF CULTURED CELLS WITH SMALL VOLUMES
(FR) DISPOSITIF AMOVIBLE DE CHAMBRE A RESERVOIRS MULTIPLES ET PROCEDE D'INCUBATION DE CELLULES DE CULTURE AYANT UNE FAIBLE VOLUME
Abstract:
(EN) A removable multi-well chamber device (2000) for incubation of cultured cells with small volumes having a first member (2320) with a planar surface and regularly spaced openings. A second member (1400) with first and second surfaces and having regularly spaced openings therethrough and is mountable to the first member (2320) so that the openings in the first (2320) and second (1400) members are in registration. The second member (1400) can be moved into and out of sealing contact with a culture surface (1100) so as to define multiple isolated wells for receiving samples. Two embodiments of the device (2000) are shown along with a method for detecting the presence of an antibody to a cell component disposed in one or more of the isolated wells.
(FR) Dispositif amovible de chambre à réservoirs multiples (2000) servant à l'incubation de cellules cultivées ayant un faible volume. Le dispositif revendiqué se compose d'un premier élément (2320) doté d'une surface plane et d'ouvertures espacées régulièrement. Un second élément (1400) possédant des surfaces primaires et secondaires et des ouvertures régulièrement espacées, peut être monté sur le premier élément (2320) de sorte que les ouvertures situées sur le premier (2320) et le second (1400) éléments concordent. Le second élément (1400) peut être introduit ou sorti du contact d'étanchéité avec une surface de culture (1100) afin de définir une pluralité de réservoirs isolés destinés à recevoir des échantillons. Deux versions du dispostif (2000) sont décrites ainsi qu'un procédé pour détecter la présence d'un anticorps contre un composant cellulaire placé dans un ou plusieurs réservoirs isolés.
Designated States: CA, JP
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)