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1. (WO1991009136) METHOD FOR THE SYNTHESIS OF SEMI-SYNTHETIC ANTIBIOTICS IN THERMODYNAMICALLY CONTROLLED WATER-COSOLVENT ORGANIC MISCIBLE APOLAR SYSTEMS BY USING PENICILLIN G ACYLASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009136 International Application No.: PCT/ES1990/000046
Publication Date: 27.06.1991 International Filing Date: 12.12.1990
IPC:
C12P 35/04 (2006.01) ,C12P 37/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
35
Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
04
by acylation of the substituent in the 7 position
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
37
Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
04
by acylation of the substituent in the 6 position
Applicants:
CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS [ES/ES]; Serrano, 117 E-28006 Madrid, ES (AllExceptUS)
GUISAN SEIJAS, José, M. [ES/ES]; ES (UsOnly)
FERNANDEZ-LAFUENTE, Roberto [ES/ES]; ES (UsOnly)
ALVARO CAMPOS, Gregorio [ES/ES]; ES (UsOnly)
BLANCO MARTIN, Rosa, Mª [ES/ES]; ES (UsOnly)
MOLINA ROSELL, Cristina [ES/ES]; ES (UsOnly)
Inventors:
GUISAN SEIJAS, José, M.; ES
FERNANDEZ-LAFUENTE, Roberto; ES
ALVARO CAMPOS, Gregorio; ES
BLANCO MARTIN, Rosa, Mª; ES
MOLINA ROSELL, Cristina; ES
Agent:
OJEDA GARCIA, Pedro; Consejo Superior Investigaciones Científicas Serrano, 117 E-28006 Madrid, ES
Priority Data:
P 890419312.12.1989ES
Title (EN) METHOD FOR THE SYNTHESIS OF SEMI-SYNTHETIC ANTIBIOTICS IN THERMODYNAMICALLY CONTROLLED WATER-COSOLVENT ORGANIC MISCIBLE APOLAR SYSTEMS BY USING PENICILLIN G ACYLASE
(ES) PROCEDIMIENTO DE SINTESIS DE ANTIBIOTICOS SEMISINTETICOS EN SISTEMAS TERMODINAMICAMENTE CONTROLADOS AGUA-COSOLVENTES ORGANICOS MISCIBLES APOLARES CON EL EMPLEO DE PENICILINA G ACILASA
(FR) PROCEDE DE SYNTHESE D'ANTIBIOTIQUES SEMI-SYNTHETIQUES DANS DES SYSTEMES REGULES THERMODYNAMIQUEMENT EAU/COSOLVANTS ORGANIQUES MISCIBLES APOLAIRES PAR UTILISATION DE PENICILLINE G ACYLASE
Abstract:
(EN) Synthesis of semi-synthetic monobactamic or $g(b)-lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/cosolvent organic apolar systems, wherein the concentration of the cosolvent varies between 30 % and 90 %, the temperature between -10 °C and 50 °C, the pH between 4.5 and 8.5, with concentrations of the antibiotic nucleus between 0.5 and 875 mM and acyl donor between 0.2 mM and 1 M, with a relationship antibiotic ring/activated or free acyl donor, using a buffer between 0 and 1 M. Application to the pharmaceutical industry.
(ES) Síntesis de antibióticos semisintéticos monobactámicos o $g(b)-lactámicos con el empleo de derivados estabilizados por distintos métodos de Penicilina G acilasa de distintas fuentes microbianas según una estrategia termodinámicamente controlada en sistemas monofásicos agua/cosolvente orgánicos apolares, donde la concentración del cosolventes oscila entre el 30 % y el 90 %, la temperatura entre -10 °C y 50 °C, el pH entre 4,5 y 8,5, con unas concentraciones de núcleo antibiótico entre 0,5 y 875 mM y de donador de acilo entre 0,2 mM y 1 M, con una relación anillo antibiótico/donador de acilo libre o activado, usando tampón entre 0 y 1 M. De aplicación en la industria farmacéutica.
(FR) Synthèse d'antibiotiques semi-synthétiques monobactamiques ou $g(b)-lactamiques par utilisation de dérivés stabilisés par divers procédés de pénicilline G acylase provenant de diverses sources microbiennes selon une stratégie régulée thermodynamiquement dans des systèmes monophases eau/cosolvants organiques apolaires, dans lesquels la concentration du cosolvant oscille entre 30 % et 90 %, la température entre -10 °C et 50 °C, le pH entre 4,5 et 8,5, avec des concentrations du noyau antibiotique entre 0,5 et 875 mM et de donneur d'acyle entre 0,2 mM et 1 M, avec une relation anneau antibiotique/donneur d'acyle libre ou activé, en utilisant un tampon entre 0 et 1 M. Application à l'industrie pharmaceutique.
Designated States: AU, BG, BR, CA, FI, HU, JP, KP, KR, LU, MC, NO, RO, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)
Also published as:
EP0458932AU1991069602