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1. (WO1991009129) STABLE INTEGRATION OF DNA IN BACTERIAL GENOMES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009129 International Application No.: PCT/DK1990/000332
Publication Date: 27.06.1991 International Filing Date: 18.12.1990
Chapter 2 Demand Filed: 20.06.1991
IPC:
C12N 15/75 (2006.01) ,C12N 15/76 (2006.01) ,C12N 15/90 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
75
for Bacillus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
76
for Actinomyces; for Streptomyces
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90
Stable introduction of foreign DNA into chromosome
Applicants:
NOVO NORDISK A/S [DK/DK]; Novo Allé DK-2880 Bagsværd, DK (AllExceptUS)
JØRGENSEN, Steen, Troels [DK/DK]; DK (UsOnly)
JØRGENSEN, Per, Linå [DK/DK]; DK (UsOnly)
DIDERICHSEN, Børge, Krag [DK/DK]; DK (UsOnly)
Inventors:
JØRGENSEN, Steen, Troels; DK
JØRGENSEN, Per, Linå; DK
DIDERICHSEN, Børge, Krag; DK
Common
Representative:
NOVO NORDISK A/S; Patent Department Novo Allé DK-2880 Bagsvaerd, DK
Priority Data:
6396/8918.12.1989DK
Title (EN) STABLE INTEGRATION OF DNA IN BACTERIAL GENOMES
(FR) INTEGRATION STABLE D'ADN DANS DES GENOMES BACTERIENS
Abstract:
(EN) A bacterial cell which in its genone carries an integrated non-replicative DNA construct comprising (1) a DNA sequence of interest, (2) a DNA sequence which is homologous with a region of the genome of the cell, and (3) an origin of replication, said DNA construct lacking a functional gene coding for a factor required to initiate replication from said origin of replication.
(FR) Cellules bactériennes portant dans son génome une structure d'ADN intégrée sans réplication, comprenant (1) une séquence d'ADN d'intérêt, (2) une séquence homologue à une région du génome de la cellule et (3) une origine de réplication, ladite structure d'ADN étant dépourvue d'un gène fonctionnel codant pour un facteur requis pour amorcer la réplication à partir de ladite origine de réplication.
Designated States: AU, CA, FI, JP, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922812NO19922381ES2064077EP0506780US5695976US5955367
US6280721US6270760JPH05502162CA2070676DE000069013520AU1991070312
DK0506780DK639689