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1. (WO1991009125) PROTEINS AND NUCLEIC ACIDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009125 International Application No.: PCT/GB1990/001911
Publication Date: 27.06.1991 International Filing Date: 07.12.1990
Chapter 2 Demand Filed: 21.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/315 (2006.01) ,C07K 14/815 (2006.01) ,C12N 9/48 (2006.01) ,C12N 9/72 (2006.01) ,C12N 15/62 (2006.01) ,C12N 15/85 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
315
from Streptococcus (G), e.g. Enterococci
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
815
from leeches, e.g. hirudin, eglin
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
72
Urokinase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
BRITISH BIO-TECHNOLOGY LIMITED [GB/GB]; Watlington Road Cowley Oxford OX4 5LY, GB (AllExceptUS)
DAWSON, Keith, Martyn [GB/GB]; GB (UsOnly)
HUNTER, Michael, George [GB/GB]; GB (UsOnly)
CZAPLEWSKI, Lloyd, George [GB/GB]; GB (UsOnly)
Inventors:
DAWSON, Keith, Martyn; GB
HUNTER, Michael, George; GB
CZAPLEWSKI, Lloyd, George; GB
Agent:
SHEARD, Andrew, Gregory ; Kilburn & Strode 30 John Street London WC1N 2DD, GB
Priority Data:
8927722.207.12.1989GB
Title (EN) PROTEINS AND NUCLEIC ACIDS
(FR) PROTEINES ET ACIDES NUCLEIQUES
Abstract:
(EN) Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation.
(FR) On peut activer des protéines de fusion relativement inactives avec des enzymes de la cascade de coagulation afin que lesdites protéines aient une activité inhibitrice de la coagulation et/ou de la fibrinolyse. Par exemple, on peut cliver une protéine de fusion comprenant deux molécules d'hirudine ou de streptokinase liées par une séquence de liaison fissible, afin de donner de l'hirudine antithrombotique ou de la streptokinase fibrinolytique par la thrombine ou le facteur Xa. L'activité inhibitrice de la coagulation ou de la fibrinolyse est donc orientée vers le site de coagulation.
Designated States: AU, CA, FI, HU, JP, KR, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922609NO19922237EP0504241US5434073JPH05502374CA2069105
KR1019920703818AU1991069540