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1. (WO1991009119) IMPROVED ALGINATE MICROCAPSULES, METHODS OF MAKING AND USING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009119 International Application No.: PCT/US1990/007275
Publication Date: 27.06.1991 International Filing Date: 10.12.1990
Chapter 2 Demand Filed: 24.04.1991
IPC:
A61K 35/14 (2006.01) ,A61K 9/16 (2006.01) ,A61K 9/50 (2006.01) ,C12N 11/04 (2006.01) ,C12N 5/071 (2010.01) ,A61K 35/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
11
Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
02
Enzymes or microbial cells being immobilised on or in an organic carrier
04
entrapped within the carrier, e.g. gel, hollow fibre
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
Applicants:
TRANCEL CORPORATION [US/US]; 1202 E. Wakeham Avenue Santa Ana, CA 92705, US
Inventors:
SKJAK-BRAEK, Gudmund; NO
SMIDSROD, Olav; NO
ESPEVIK, Terje; NO
OTTERLEI, Marit; NO
Agent:
GERIAK, James, W. ; 611 West Sixth Street 34th Floor Los Angeles, CA 90017, US
Priority Data:
449,98313.12.1989US
Title (EN) IMPROVED ALGINATE MICROCAPSULES, METHODS OF MAKING AND USING SAME
(FR) MICROCAPSULES D'ALGINATE AMELIOREES ET PROCEDES POUR LEUR FABRICATION ET LEUR UTILISATION
Abstract:
(EN) A composition for containing biological material for $i(in vivo) implantation and transplantation comprising alginate cross-linked with barium salt, preferably barium chloride. The microcapsule may optionally have as its other layers hyaluronic acid and poly-L-lysine. Also alginate cross-linked with both calcium chloride and barium chloride may be used. The microcapsule of the present invention is rugged and retains a strong negative charge, enhancing the release of protein and limiting the invasion of immunoglobulins. The microcapsule may preferably be used for encapsulating islets of Langerhans for the production of insulin.
(FR) Une composition permettant de contenir un matériau biologique destiné à l'implantation $i(in vivo) et la transplantation comprenant de l'alginate réticulé avec du sel de baryum, de préférence du chlorure de baryum. La microcapsule est susceptible de comporter facultativement comme ses autres couches de l'acide hyaluronique et de la poly-L-lysine. On peut également utiliser de l'alginate réticulé avec du chlorure de calcium aussi bien que du chlorure de baryum. La microcapsule décrite est rugueuse et conserve une forte charge négative, améliorant la libération de protéines et limitant l'invasion par des immunoglobulines. La microcapsule peut être utilisée de préférence pour l'encapsulation des îlots de Langerhans en vue de la production d'insuline.
Designated States: AT, FI, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)