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1. (WO1991009059) ANTIBODY ANTAGONISTS OF HUMAN INTERLEUKIN-4
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009059 International Application No.: PCT/US1990/007289
Publication Date: 27.06.1991 International Filing Date: 18.12.1990
Chapter 2 Demand Filed: 11.07.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/54 (2006.01) ,C07K 16/24 (2006.01) ,C07K 16/42 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42
against immunoglobulins (anti-idiotypic antibodies)
Applicants:
SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road Kenilworth, NJ 07033, US (AllExceptUS)
RAMANATHAN, Lata [IN/US]; US (UsOnly)
SEELIG, Gail, F. [US/US]; US (UsOnly)
TROTTA, Paul, P. [US/US]; US (UsOnly)
Inventors:
RAMANATHAN, Lata; US
SEELIG, Gail, F.; US
TROTTA, Paul, P.; US
Agent:
DULAK, Norman, C. ; Schering-Plough Corporation One Giralda Farms Madison, NJ 07940-1000, US
Priority Data:
453,57020.12.1989US
Title (EN) ANTIBODY ANTAGONISTS OF HUMAN INTERLEUKIN-4
(FR) ANTAGONISTES D'ANTICORPS DE L'INTERLEUCINE-4 HUMAINE
Abstract:
(EN) Two kinds of antibody antagonists of the binding of human IL-4 to cellular receptors are provided by this invention. Some of the antagonists bind to specific regions of IL-4 which are believed to be involved in interactions between IL-4 and its receptors. Because of this specific binding by the antibodies to the IL-4, the binding of the IL-4 to the receptors is substantially inhibited. The other antibody antagonists of the invention are anti-idiotypic antibodies which, while lacking IL-4 activity, appear to mimic IL-4 and to compete directly with it for binding to the cellular receptors. Polypeptides used to make the antibody antagonists are also provided, together with methods for using the antagonists to inhibit the binding of IL-4 to its cellular receptors.
(FR) Deux genres d'antagonistes d'anticorps contre la liaison de l'IL-4 humaine aux récepteurs cellulaires sont décrits. Certains des antagonistes se lient à des régions spécifiques de l'IL-4 qui semblent être impliquées dans les interactions entre l'IL-4 et ses récepteurs. Grâce à cette liaison spécifique des anticorps à l'IL-4, on inhibe très considérablement la liaison de l'IL-4 aux récepteurs. Les autres antagonistes d'anticorps de l'invention sont anti-idiotypiques et, tout en étant dépourvus d'activité IL-4, semblent mimer l'IL-4 et être ses concurrents directs pour la liaison avec les récepteurs cellulaires. On décrit également les polypeptides utilisés pour produire les antagonistes d'anticorps, ainsi que des méthodes d'utilisation des antagonistes pour inhiber la liaison de l'IL-4 à ses récepteurs cellulaires.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922847NO19922457EP0506826ES2085983JPH04506359CA2071908
DE000069026627PT96230KR1019920703642AU1991071762DK0506826ID001.710