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1. (WO1991009057) NOVEL PROTEINS WITH ONCOSTATIN M ACTIVITY AND PROCESS FOR THEIR PREPARATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009057 International Application No.: PCT/US1990/007227
Publication Date: 27.06.1991 International Filing Date: 07.12.1990
Chapter 2 Demand Filed: 08.07.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
Applicants:
ONCOGEN LIMITED PARTNERSHIP [US/US]; 3005 First Avenue Seattle, WA 98121, US
Inventors:
LINSLEY, Peter, S.; US
KALLESTAD, Jeffrey, C.; US
Agent:
MISROCK, S., Leslie; Pennie & Edmonds 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
447,75908.12.1989US
Not furnished03.12.1990US
Title (EN) NOVEL PROTEINS WITH ONCOSTATIN M ACTIVITY AND PROCESS FOR THEIR PREPARATION
(FR) NOUVELLES PROTEINES A ACTIVITE D'ONCOSTATINE M ET PROCEDE DE PREPARATION
Abstract:
(EN) The present invention is directed to biologically mutant forms of the cell growth regulatory factor Oncostatin M. The Oncostatin M mutants of the invention comprise deletion, substitution and insertion mutants and may be prepared using recombinant DNA, $i(in vitro) mutagenesis and heterologous expression techniques. Oncostatin M mutants may be useful in eliciting Oncostatin M biological responses and, as such, may find a variety of therapeutic uses including but not limited to the treatment of neoplasias.
(FR) La présente invention se rapporte à des formes biologiquement mutantes du facteur régulateur de croissance cellulaire Oncostatine M. Les mutants de l'Oncostatine M objets de l'invention incluent des mutants de suppression, de substitution et d'insertion et peuvent être préparés à l'aide de techniques de recombinaison d'ADN, de mutagénèse $i( in vitro) et d'expression hétérologue. Les mutants de l'Oncostatine M peuvent être utiles pour déterminer les réactions biologiques de l'Oncostatine M et, à ce titre, trouvent de nombreuses applications thérapeutiques incluant, sans limitation, le traitement des néoplasies.
Designated States: AU, CA, FI, HU, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922612NO19922202EP0504291JPH05504134CA2070171KR1019920703636
AU1991070361DK0504291