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1. (WO1991009052) CHROMOGENIC SUBSTRATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009052 International Application No.: PCT/SE1990/000797
Publication Date: 27.06.1991 International Filing Date: 03.12.1990
Chapter 2 Demand Filed: 14.06.1991
IPC:
C07K 5/103 (2006.01) ,C07K 11/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
103
the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
11
Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants:
KABI DIAGNOSTICA AB [SE/SE]; Taljegårdsgatan 3 S-431 53 Mölndal, SE (AllExceptUS)
ARIELLY, Salo [SE/SE]; SE (UsOnly)
Inventors:
ARIELLY, Salo; SE
Agent:
BERGANDER, Håkan; Kabi Pharmacia AB S-751 82 Uppsala, SE
Priority Data:
8904188-312.12.1989SE
Title (EN) CHROMOGENIC SUBSTRATE
(FR) SUBSTRAT CHROMOGENE
Abstract:
(EN) The invention relates to novel peptide derivatives with the formula: R1-A1-A2-A3-A4-R2 or its salt, wherein R1 = H or a protective group; A1 = H, Ile, Leu or Val; A2 = Glu, Asp, Ser, Thr; A3 = Gly or Glyc; A4 = Arg or Lys; R2 = 4-nitro aniline with the proviso that A3 is Gly when A4 is Lys and that A3 is Glyc when A4 is Arg. The invention also discloses the process for the preparation of the peptide derivatives, the method for the determination of the bacterial endotoxins by the use of the invented peptide derivatives and the use of these derivatives for determination of bacterial endotoxins.
(FR) On décrit de nouveaux dérivés peptidiques correspondant à la formule, R1-A1-A2-A3-A4-R2 ou un sel de ces dérivés. Dans la formule R1 = H ou un groupe protecteur; A1 = H, Ile, Leu ou Val; A2 = Glu, Asp, Ser, Thr; A3 = Gly ou Glyc; A4 = Arg ou Lys; R2 = aniline 4-nitro à condition que A3 soit Gly lorsque A4 est Lys, et A3 soit Glyc lorsque A4 est Arg. On décrit également le procédé de préparation des dérivés peptidiques, le procédé de détermination des endotoxines bactériennes à l'aide des dérivés peptidiques précités, et l'utilisation de ceux-ci pour la détermination des endotoxines bactériennes.
Designated States: AU, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
ES2098344EP0505428US5334703JPH05506209DE000069030102AU1991069579