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1. (WO1991009045) HEPATOCELLULAR CARCINOMA ONCOGENE
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WHAT IS CLAIMED IS:
I . A DNA fragment coding for the amino acid sequence set forth in Figure 1 or an allelic variation of said sequence, or a unique portion thereof.
2. The DNA fragment according to claim 1 wherein said fragment codes for the amino acid sequence set forth in Figure 1, or a unique portion thereof.
3. A recombinant DNA molecule comprising:
i) a vector, and
ii) said DNA fragment according to claim 1.
4. The recombinant molecule according to claim 3 wherein said DNA fragment codes for the amino acid sequence set forth in Figure 1, or a unique portion thereof.
5. The recombinant DNA molecule according to claim 3 further comprising a promoter sequence operably linked to said DNA fragment.
6. A host cell transformed with the recombinant DNA molecule according to claim 5.
7. The host cell according to claim 6 , wherein said cell is a procaryotic cell.
8. The host cell according to claim 7, wherein said cell is an E . coli cell.
9. A nucleotide fragment sufficiently complementary to said DNA fragment according to claim 1 to hybrid-ize therewith.
10. A protein having the amino acid sequence set forth in Figure 1 or an allelic variation of said sequence, or a unique portion thereof.
II. The protein according to claim 10 wherein said protein has the amino acid sequence set forth in

Figure 1, or a unique portion thereof.
12. Antibodies specific for said protein according to claim 10.
13. The antibodies according to claim 12, wherein said antibodies are polyclonal.
14. A process of producing the protein according to claim 10 comprising
culturing a host cell transformed with a recombinant DNA molecule comprising:
i) a vector, and
ii) a DNA fragment coding for said protein under conditions such that said DNA fragment is expressed and said protein thereby produced; and
isolating said protein.
15. A method of detecting the presence of the protein according to claim 10 in a sample comprising:
i) contacting the sample with an antibody specific for said protein under conditions such that binding of said antibody to said protein can occur, whereby a complex is formed; and
ii) assaying for the presence of said complex.
16. The method according the claim 15 wherein said antibody is linked to a detectable label.
17. A method of detecting the presence of a nucleotide sequence coding for said protein according to claim 10 in a sample comprising:
i) contacting the sample with a nucleotide fragment sufficiently complementary to said nucleotide sequence to hybridize therewith under conditions such that hybridization can occur, whereby a complex is formed, and ii) assaying for the presence of said complex.
18. The method according to claim 17 wherein said nucleotide fragment is linked to a detectable label.
19. A method of diagnosing the presence of hepatocellular carcinoma in a patient comprising:
i) contacting a biological sample from said patient with an antibody according to claim 12 under conditions such that binding of said antibody to said protein present in said sample can occur, whereby a complex is formed; and
ii) assaying for the presence of said complex.
20. The method according to claim 19 wherein said sample is a tissue sample.

21. A method of diagnosing the presence of hepatocellular carcinoma in a patient comprising:
i) contacting nucleic acid sequences derived from a cellular sample from said patient with said nucleotide fragment according to claim 9 under conditions such that hybridization can occur, whereby a complex is formed; and
ii) assaying for the presence of said complex.
22. A diagnostic kit for detecting the presence of the protein according to claim 10 in a sample comprising a container means having disposed therewithin antibodies specific for said protein.
23. A diagnostic kit for detecting the presence of a nucleic acid sequence coding for a protein having the amino acid sequence set forth in Figure 1 or an allelic variation of said sequence, or a unique portion thereof, comprising a container means having disposed therewithin said nucleotide fragment according to claim 9.