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1. (WO1991009036) BETA-LACTAM DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009036 International Application No.: PCT/EP1990/002189
Publication Date: 27.06.1991 International Filing Date: 14.12.1990
Chapter 2 Demand Filed: 21.05.1991
IPC:
C07D 501/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
501
Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Applicants:
FARMITALIA CARLO ERBA S.R.L. [IT/IT]; Via Carlo Imbonati, 24 I-20159 Milan, IT (AllExceptUS)
BISSOLINO, Pierluigi [IT/IT]; IT (UsOnly)
ALPEGIANI, Marco [IT/IT]; IT (UsOnly)
PERRONE, Ettore [IT/IT]; IT (UsOnly)
OREZZI, Piergiuseppe [IT/IT]; IT (UsOnly)
CASSINELLI, Giuseppe [IT/IT]; IT (UsOnly)
FRANCESCHI, Giovanni [IT/IT]; IT (UsOnly)
Inventors:
BISSOLINO, Pierluigi; IT
ALPEGIANI, Marco; IT
PERRONE, Ettore; IT
OREZZI, Piergiuseppe; IT
CASSINELLI, Giuseppe; IT
FRANCESCHI, Giovanni; IT
Agent:
WOODS, Geoffrey, Corlett ; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data:
8928373.315.12.1989GB
Title (EN) BETA-LACTAM DERIVATIVES
(FR) DERIVES DE BETA-LACTAME
Abstract:
(EN) Cephalosporins of formula (I), wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for their preparation starting from the corresponding 4-acyl cephem are also provided.
(FR) L'invention se rapporte à des céphalosporines représentées par la formule (I), où m est égal à 1 ou à 2, n est égal à zéro, à 1 ou à 2, A et B représentent des résidus organiques, et R1 et R2 représentent des groupes organiques ou des atomes d'halogène ou d'hydrogène, ces céphalosporines étant dotées d'un pouvoir inhibiteur de l'élastase. Deux procédés permettant la préparation de ces composés en partant du céphème 4-acyle correspondant sont également décrits.
Designated States: AU, CA, FI, HU, JP, KR, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922738ZA1990/10037ES2063488EP0505413RU02074186US5348952
JPH05502225CA2071885DE000069012145PT96192KR1019920703606KR1019937002723
KR1019977003012KR1019977003013KR1019977003031KR1019977003014AU1991069620DK0505413
MYPI 90002172