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1. (WO1991009034) INDOLOCARBAZOLES FROM SACCHAROTHRIX AEROCOLONIGENES SUBSP. COPIOSA SUBSP. NOV. SCC 1951 ATCC 53856
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009034 International Application No.: PCT/US1990/007174
Publication Date: 27.06.1991 International Filing Date: 12.12.1990
Chapter 2 Demand Filed: 08.07.1991
IPC:
C07D 487/14 (2006.01) ,C07D 498/22 (2006.01) ,C12P 17/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
22
in which the condensed system contains four or more hetero rings
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
18
containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Applicants:
SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road Kenilworth, NJ 07033, US
Inventors:
BARRABEE, Ellen, B.; US
HORAN, Ann, C.; US
GENTILE, Frank, A.; US
PATEL, Mahesh, G.; US
Agent:
HOFFMAN, Thomas, D. ; Schering-Plough Corporation One Giralda Farms Madison, NJ 07940-1000, US
Priority Data:
451,27114.12.1989US
451,48714.12.1989US
Title (EN) INDOLOCARBAZOLES FROM SACCHAROTHRIX AEROCOLONIGENES SUBSP. COPIOSA SUBSP. NOV. SCC 1951 ATCC 53856
(FR) INDOLOCARBAZOLS PROVENANT DE SACCHAROTHRIX AEROCOLONIGENES SUBSP. COPIOSA SUBSP. NOV. SCC 1951, ATCC 53856
Abstract:
(EN) The indolocarbazoles represented by formula (I) wherein Ra and Rb are each H or Ra and Rb taken together are A or B wherein R1 and R2 are independently H or OH or OCH3 and R3 is OH, NHCH3, NCH3 COCH3 or NHCOCH3 and R4 is OH or H and, stereochemical isomers thereof or pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed with the provisos that (1) when Ra and Rb together are A, and R1=H or OH, R3 is not NHCH3; (2) when Ra and Rb together are B, then R1=R4=H; (3) when Ra=Rb=H R1=-OCH3, and (4) when Ra and Rb taken together are A, and R1=H, R3 is not (II).
(FR) L'invention concerne les indolocarbozols représentés par la formule (I), dans laquelle Ra et Rb représente chacun H ou Ra et Rb pris ensemble représentent A ou B, dans lesquelles R1 et R2 représentent indépendemment H ou OH ou OCH3 et R3 représente OH, NHCH3, NCH3COCH3 ou NHCOCH3 et R4 représente OH ou H, et leurs isomères stéréochimiques ou leurs compositions pharmaceutiques utiles pour inhiber la kinase à chaînes légères de myosine, la kinase C protéique ou la prolifération de cellules tumorales, ainsi que pour produire un effet antihypertensif et un effet antiinflammatoire chez les animaux à sang chaud et chez l'homme, aux conditions que (1) lorsque Ra et Rb repreésentent ensemble A, et R1=H ou OH, R3 ne représente pas NHCH3; (2) lorsque Ra et Rb représentent ensemble B, alors R1=R4=H; (3) lorsque Ra=Rb=H R1=-OCH3, et (4) lorsque Ra et Rb représentent ensemble A, et R1=H, R3 ne représente pas (II).
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991070359