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1. (WO1991009033) UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009033 International Application No.: PCT/US1990/007563
Publication Date: 27.06.1991 International Filing Date: 20.12.1990
Chapter 2 Demand Filed: 09.07.1991
IPC:
C07H 21/00 (2006.01) ,C08G 79/02 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
79
Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon
02
a linkage containing phosphorus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
ANTI-GENE DEVELOPMENT GROUP; 240 S.W. Avery Avenue Corvallis, OR 97333, US
Inventors:
SUMMERTON, James, E.; US
WELLER, Dwight, D.; US
Agent:
DEHLINGER, Peter, J.; 350 Cambridge Avenue, #100 Palo Alto, CA 94306, US
Priority Data:
454,05720.12.1989US
Title (EN) UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES
(FR) POLYMERES NON CHARGES A BASE DE MORPHOLINE AYANT DES LIAISONS CHIRALES PHOSPHOREUSES ENTRE LES SOUS-UNITES
Abstract:
(EN) A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, phosphorous-containing chiral linkages, one to three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
(FR) Une composition polymère est composée de sous-unités à structure à base de morpholine mutuellement reliées par des liaisons chirales phosphoreuses non chargées d'un à trois atomes de longueur. Ces liaisons chirales relient l'azote morpholinique d'une sous-unité au carbone exocyclique en 5' d'une sous-unité adjacente. Chaque sous-unité contient une moitié d'appariement à base de purine ou de pyrimidine capable de se lier par une liaison hydrogène à une base ou à une paire de bases spécifiques d'un polynucléotide voulu.
Designated States: AU, CA, JP, KR
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0506830EP0962463JP3398378JPH05504563JP2002167441 CA2069869
DE000069033986DE000069034213KR1019920703584AU1991071642