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1. (WO1991009030) 2-SUBSTITUTED 4,5-DIPHENYL-IMIDAZOLES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009030 International Application No.: PCT/EP1990/002147
Publication Date: 27.06.1991 International Filing Date: 11.12.1990
Chapter 2 Demand Filed: 11.07.1991
IPC:
C07D 233/84 (2006.01) ,C07D 401/12 (2006.01) ,C07D 403/12 (2006.01) ,C07D 413/12 (2006.01) ,C07D 417/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
66
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
84
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
RHONE-POULENC SANTE [FR/FR]; 20, avenue Raymond-Aron F-92165 Antony Cédex, FR (AllExceptUS)
BRIDGE, Andrew, William [GB/GB]; GB (UsOnly)
HARRIS, Neil, Victor [GB/GB]; GB (UsOnly)
LYTHGOE, David, John [GB/GB]; GB (UsOnly)
SMITH, Christopher [GB/GB]; GB (UsOnly)
Inventors:
BRIDGE, Andrew, William; GB
HARRIS, Neil, Victor; GB
LYTHGOE, David, John; GB
SMITH, Christopher; GB
Agent:
BENTHAM, Stephen ; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data:
8928028.312.12.1989GB
9000697.412.01.1990GB
9000698.212.01.1990GB
Title (EN) 2-SUBSTITUTED 4,5-DIPHENYL-IMIDAZOLES
(FR) 4,5-DIPHENYLE-IMIDAZOLES SUBSTITUEES EN POSITION 2
Abstract:
(EN) Imidazole derivatives of the formula (I): [DPIM]-S-W-Y, wherein [DPIM] represents a group of formula (DPIM), wherein R and R1 represent hydrogen, halogen or alkyl, W represents straight chain alkylene of 1 to 6 carbon atoms optionally substituted by alkyl, Y represents a group of formulas (II), (III), (IV), (V), (VI) and salts thereof, are inhibitors of acyl coenzyme-A:cholesterol-O-acyl transferase useful for the conditions such as atherosclerosis, hyperlipidaemia, cholesterol or ester storage disease and atheroma in vein grafts.
(FR) Dérivés d'imidazole répondant à la formule (I), dans laquelle [DPIM] représente un groupe de formule (DPIM), où R et R1 représentent hydrogène, halogène ou alkyle, W représente alkylène rectiligne en C1-6 éventuellement substitué par alkyle, Y représente un groupe de formule (II), (III), (IV), (V), (VI), et leurs sels, inhibent le coenzyme-A acylique: cholestérol-O-acyl- transférase utile au traitement des troubles tels que l'athérosclérose, l'hyperlipidémie, la polycorie cholestérolique et l'athérome des greffes veineuses.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0505481JPH05502235CA2071497