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1. (WO1991009028) THERAPEUTICALLY ACTIVE FLUORO SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009028 International Application No.: PCT/SE1990/000839
Publication Date: 27.06.1991 International Filing Date: 17.12.1990
Chapter 2 Demand Filed: 12.06.1991
IPC:
C07D 401/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
AKTIEBOLAGET HÄSSLE [SE/SE]; S-431 83 Mölndal, SE
Inventors:
BRÄNDSTRÖM, Arne; SE
LINDBERG, Per; SE
SUNDÉN, Gunnel; SE
Agent:
MIKSCHE, Gerhard ; AB Astra Patent Department S-151 85 Södertälje, SE
Priority Data:
454,04820.12.1989US
Title (EN) THERAPEUTICALLY ACTIVE FLUORO SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE
(FR) BENZIMIDAZOLES FLUORO-SUBSTITUES THERAPEUTIQUEMENT ACTIFS, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION
Abstract:
(EN) The novel compounds of formula (I), wherein F is in 5 or 6 position, and formula (I'), wherein in both formulas R is the group -CH2OCOOR1, wherein R1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R1 is the group (a), -(CH2)n-COOH or -(CH2)n-SO3H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.
(FR) Composés nouveaux, leurs sels physiologiquement acceptables et leurs intermédiaires, ayant les formules (I) et (I'), dans lesquelles F est en 5e ou 6e position (dans la formule I) et R (dans les deux formules) représente le groupe -CH2OCOOR1, R1 étant un alkyle à chaîne droite ou ramifiée contenant entre 1 et 6 atomes de carbone, ou benzyle, ou R1 étant un des groupes (a), -(CH2)n-COOH ou -(CH2)n-SO3H, dans lesquels n est compris entre 1 et 6. On décrit des compositions pharmaceutiques contenant ces composés en tant qu'ingrédients actifs et l'utilisation de ces composés en médecine.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922864NO19922437IL96397ZA1990/09142EP0506759CA2070651
KR1019927003573AU1991070380MYPI 90002189