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1. (WO1991009021) IMIDAZOLES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009021 International Application No.: PCT/EP1990/002146
Publication Date: 27.06.1991 International Filing Date: 11.12.1990
Chapter 2 Demand Filed: 11.07.1991
IPC:
C07D 233/84 (2006.01) ,C07D 401/12 (2006.01) ,C07D 403/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
66
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
84
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
RHONE-POULENC SANTE [FR/FR]; 20, avenue Raymond-Aron F-92165 Antony Cédex, FR (AllExceptUS)
BRIDGE, Andrew, William [GB/GB]; GB (UsOnly)
HARRIS, Neil, Victor [GB/GB]; GB (UsOnly)
LYTHGOE, David, John [GB/GB]; GB (UsOnly)
SMITH, Christopher [GB/GB]; GB (UsOnly)
Inventors:
BRIDGE, Andrew, William; GB
HARRIS, Neil, Victor; GB
LYTHGOE, David, John; GB
SMITH, Christopher; GB
Agent:
BENTHAM, Stephen ; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data:
8927953.311.12.1989GB
9017844.314.08.1990GB
Title (EN) IMIDAZOLES
(FR) IMIDAZOLES
Abstract:
(EN) Imidazole derivatives of formula (I) wherein A represents methylene or a group -CH2-A'-CH2- wherein A' represents a direct bond, linear alkanediyl, alkenediyl or alkynediyl, hydroxymethylene, or optionally substituted phenylene; R1 and R2 each represents hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylamino, carboxy or alkoxycarbonyl; a and b are 0, 1 or 2; and Het represents a heterocyclic group containing from 5 to 7 ring atoms chosen from carbon, nitrogen, sulphur and oxygen atoms, and salts thereof are inhibitors of acyl coenzyme-A: cholesterol-O-acyl transferase useful for the treatment of conditions such as atherosclerosis, hyperlipidaemia, cholesterol ester storage disease and atheroma in vein grafts.
(FR) Dérivés d'imidazole répondant à la formule (I), dans laquelle A représente méthylène ou un groupe -CH2-A'-CH2- dans lequel A' représente une liaison directe, alcanediyle linéaire, alkylènediyle ou alkynediyle, hydroxyméthylène, ou phénylène éventuellement substitué; R1 et R2 représentent chacun hydrogène, halogène, alkyle, alcoxy, alkylthio, alkylamino, carboxy, ou alcocarbonyle; a et b sont 0, 1 ou 2; et Het représente un groupe hétérocyclique qui contient de 5 à 7 atomes cycliques sélectionnés parmi des atomes de carbone, azote, soufre ou oxygène, et leurs sels sont des inhibiteurs du coenzyme -A acylique: cholestérol -O-acyl-transférase utile au traitement des troubles tels que l'athérosclérose, l'hyperlipidémie, la polycorie cholestérolique et l'athérome des greffes veineuses.
Designated States: AU, CA, FI, HU, JP, KR, NO, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0505468CA2071498AU1991070492