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1. (WO1991009017) QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/009017 International Application No.: PCT/JP1990/001617
Publication Date: 27.06.1991 International Filing Date: 10.12.1990
Chapter 2 Demand Filed: 05.07.1991
IPC:
C07D 215/38 (2006.01) ,C07D 405/12 (2006.01) ,C07D 417/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 3-6, Doshomachi 2-chome Chuo-ku Osaka-shi Osaka 541, JP (AllExceptUS)
MEGURO, Kanji [JP/JP]; JP (UsOnly)
IKEDA, Hitoshi [JP/JP]; JP (UsOnly)
Inventors:
MEGURO, Kanji; JP
IKEDA, Hitoshi; JP
Agent:
NOGAWA, Shintaro; Quarter-1 Bldg. 1-3, Nishitenma 5-chome Kita-ku Osaka-shi Osaka 530, JP
Priority Data:
1/32217211.12.1989JP
Title (EN) QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE
(FR) DERIVES DE QUINOLEINE, LEUR FABRICATION ET LEUR UTILISATION
Abstract:
(EN) A quinoline derivative of formula (I), wherein each phenyl ring of A and B can have one or more substituents; X is (II) (R1 is a hydrogen atom, a lower alkyl group or a lower alkoxy group) or (III) (R2 is a hydrogen atom or a lower alkyl group); Y is -(CH2)m-(m is 0, 1 or 2) or -CH=CH-, Z is a group of formulae (IV), (V) or (VI), wherein each phenyl ring of C and D can have one or more substituents, R3 and R4 are each a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, N,N-di-lower alkylcarbamoyloxy, optionally esterified carboxy or hydroxyl group, R5 is a halogen atom, or a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, N,N-di-lower alkylcarbamoyloxy, optionally esterified carboxy or hydroxyl group, R6 and R7 are each a hydrogen atom or a lower alkyl group, and n, o and p are each 1 or 2; l is 0 or 1; or its salt, which is useful as a drug for atherosclerosis.
(FR) Dérivé de quinoléine correspondant à la formule (I), dans laquelle chaque anneau phénylique de A et B peut comprendre un ou plusieurs substituants; X est (II) (où R1 est un atome d'hydrogène, un groupe alkyle inférieur ou un groupe alcoxy inférieur) ou (III) (où R2 est un atome d'hydrogène ou un groupe alkyle inférieur); Y est -(CH2)m-(m est 0, 1 ou 2) ou -CH=CH-, Z est un groupe qui répond aux formules (IV), (V) ou (VI), dans lesquelles chaque anneau phénylique de C ou D peut comprendre un ou plusieurs substituants; R3 et R4 sont chacun un atome d'hydrogène ou d'halogène, ou un groupe alkyle inférieur, alcoxy inférieur, acyloxy inférieur, alcoxycarbonyloxy inférieur, alkylcarbamoyloxy, N,N-di-inférieur, carboxy éventuellement estérifié, ou hydroxyle; R5 est un atome d'halogène, ou un groupe alkyle inférieur, alcoxy inférieur, acyloxy inférieur, alcoxycarbonyloxy inférieur, alkylcarbamoyloxy, N,N-di-inférieur, carboxy éventuellement estérifié, ou hydroxyle; R6 et R7 sont chacun un atome d'hydrogène ou un groupe alkyle inférieur; et n, o et p sont chacun 1 ou 2; l est 0 ou 1. On décrit également le sel de ce dérivé, qui est utile en tant que médicament pour l'athérosclérose.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0505565US5362742US5523407JPH06503550CA2071224