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1. (WO1991008748) SYNTHESIS OF ROTAVIRUS RECEPTOR SACCHARIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008748 International Application No.: PCT/US1990/007121
Publication Date: 27.06.1991 International Filing Date: 05.12.1990
Chapter 2 Demand Filed: 24.06.1991
IPC:
C07H 13/04 (2006.01) ,C07H 15/04 (2006.01) ,C07H 15/06 (2006.01) ,C07H 15/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13
Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02
by carboxylic acids
04
having the esterifying carboxyl radicals attached to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
06
being a hydroxyalkyl group esterified by a fatty acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
18
Acyclic radicals, substituted by carbocyclic rings
Applicants:
GLYCOMED INCORPORATED [US/US]; 860 Atlantic Avenue Alameda, CA 94501, US
Inventors:
ABBAS, Saeed, A.; US
NASHED, Mina, A.; US
DASGUPTA, Falguni; US
SRNKA, Cheryl, A.; US
LAINE, Roger, A.; US
Agent:
BOZICEVIC, Karl ; Irell & Manella 545 Middlefield Road Suite 200 Menlo Park, CA 94025, US
Priority Data:
450,02613.12.1989US
554,00517.07.1990US
Title (EN) SYNTHESIS OF ROTAVIRUS RECEPTOR SACCHARIDES
(FR) SYNTHESE DE SACCHARIDES RECEPTEURS DE ROTAVIRUS
Abstract:
(EN) Saccharides which are active as rotavirus receptor sites are disclosed. These saccharides are synthetically produced sugar derivatives recognized by the antireceptor of a rotavirus. The molecules are useful in studying the interaction between the rotavirus antireceptor and most receptor sites so as to develop drugs useful in blocking the connection between such viruses and the host cells. Further, the molecules can be modified in order to increase the degree to which they attract the antireceptor sites of the virus and/or modified by binding to them antiviral compounds which are effective in destroying the virus once the receptor molecule binds to the virus. Synthetic receptor molecules recognizable by a rotavirus are obtainable by the synthesis methods disclosed.
(FR) L'invention se rapporte aux saccharides actifs en tant que récepteurs de rotavirus. Ces saccharides sont des dérivés de sucres synthétiques reconnus par l'antirécepteur d'un rotavirus. Les molécules ont pour utilité d'étude de l'interaction entre l'antirécepteur du rotavirus et la plupart des sites récepteurs afin de développer des médicaments utiles au blocage de la connexion entre ces virus et les cellules hôtes. De plus, les molécules peuvent être modifiées afin d'augmenter le degré auquel elles attirent les sites antirécepteurs du virus et/ou modifiées par liaison sur celles-ci de composés antiviraux efficaces pour détruire le virus quand la molécule du récepteur se combine avec le virus. Des molécules réceptrices synthétiques reconnaissables par un rotavirus peuvent être obtenues par les procédés de synthèse objets de l'invention.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991071539