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1. (WO1991008747) SYNTHETIC RECEPTOR MOLECULES RECOGNIZABLE BY A ROTAVIRUS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008747 International Application No.: PCT/US1990/007120
Publication Date: 27.06.1991 International Filing Date: 05.12.1990
Chapter 2 Demand Filed: 24.06.1991
IPC:
C07H 13/04 (2006.01) ,C07H 15/04 (2006.01) ,C07H 15/06 (2006.01) ,C07H 15/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13
Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02
by carboxylic acids
04
having the esterifying carboxyl radicals attached to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
06
being a hydroxyalkyl group esterified by a fatty acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
18
Acyclic radicals, substituted by carbocyclic rings
Applicants:
GLYCOMED INCORPORATED [US/US]; 860 Atlantic Avenue Alameda, CA 94501, US
Inventors:
DASGUPTA, Falguni; US
SRNKA, Cheryl, A.; US
LAINE, Roger, A.; US
Agent:
BOZICEVIC, Karl ; Irell & Manella 545 Middlefield Road, Suite 200 Menlo Park, CA 94025, US
Priority Data:
450,02613.12.1989US
554,00517.07.1990US
566,68813.08.1990US
Title (EN) SYNTHETIC RECEPTOR MOLECULES RECOGNIZABLE BY A ROTAVIRUS
(FR) MOLECULES RECEPTRICES SYNTHETIQUES RECONNAISSABLES A L'AIDE D'UN ROTAVIRUS
Abstract:
(EN) Molecules which are active as rotavirus receptor sites are disclosed. These molecules are synthetically produced sugar derivatives which have a minimum size recognized by the antireceptor of a rotavirus. The molecules are useful in studying the interaction between the rotavirus antireceptor and most receptor sites so as to develop drugs useful in blocking the connection between such viruses and the host cells. Further, the molecules can be modified in order to increase the degree to which they attract the antireceptor sites of the virus and/or modified by binding to them antiviral compounds which are effective in destroying the virus once the receptor molecule binds to the virus. Synthetic receptor molecules recognizable by a rotavirus are obtainable by modifying the hydroxyl sites of N-acetyl-D-galactosamine (GalNAc) in the immediate vicinity of the glycosidic linkage of GalNAc. Similar modifications of other sugar residues are taught in order to obtain similar synthetic receptor molecules which are recognizable by a rotavirus as a receptor.
(FR) On décrit des molécules qui sont actives comme sites de récepteurs de rotavirus. On obtient synthétiquement ces molécules à partir de dérivés de sucre qui possèdent une grandeur minimum reconnue par l'antirécepteur d'un rotavirus. Les molécules sont utiles pour l'étude de l'interaction entre l'antirécepteur et la plupart des sites de récepteur afin de développer des médicamments utiles pour le blocage de la connexion entre de tels virus et les cellules hôtes. De plus, on peut modifier les molécules de façon à augmenter le degré auquel elles attirent les sites antirécepteurs du virus et/ou les modifier en faisant fixer à celles-ci de composés antiviraux qui sont efficaces quant à la destruction du virus une fois que la molécule réceptrice se lie au virus. On peut obtenir des molécules réceptrices synthétiques reconnaissables à l'aide d'un rotavirus par la modification des sites hydroxyles de N-acétyle-D-galactosamine (GaLNAc) dans la proximité immédiate de la liaison glycosidique du GalNac. On enseigne des modifications semblables à d'autres résidus de sucre afin d'obtenir des molécules réceptrices synthétiques similaires qui sont reconnaissables à l'aide d'un rotavirus comme récepteur.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991069026