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1. (WO1991008745) COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ROTAVIRAL INFECTIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008745 International Application No.: PCT/US1990/007346
Publication Date: 27.06.1991 International Filing Date: 13.12.1990
Chapter 2 Demand Filed: 24.06.1991
IPC:
A61K 31/575 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Applicants:
GLYCOMED INCORPORATED [US/US]; 860 Atlantic Avenue Alameda, CA 94501, US
Inventors:
SRNKA, Cheryl; US
LAINE, Roger, A.; US
GILBERT, James; US
Agent:
ROBINS, Roberta, L.; Irell & Manella 545 Middlefield Road Suite 200 Menlo Park, CA 94025, US
Priority Data:
450,19813.12.1989US
Title (EN) COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ROTAVIRAL INFECTIONS
(FR) COMPOSITIONS ET PROCEDES DE PREVENTION ET DE TRAITEMENT D'INFECTIONS ROTAVIRALES
Abstract:
(EN) Compositions useful in the prevention and treatment of rotaviral infections are disclosed. The subject compositions contain cholesterol 3-sulfate or functional derivatives thereof. Cholesterol 3-sulfate avidly binds rotavirus in thin layer overlay assays and inhibits rotavirus in plaque reduction assays. These compositions can be used to prevent and ameliorate rotaviral infections.
(FR) Compositions utiles dans la prévention et dans le traitement d'infections rotavirales. Les compositions de l'invention contiennent du 3-sulfate cholestérolique ou des dérivés fonctionnels de celui-ci. Le 3-sulfate cholestérolique lie le rotavirus dans des dosages d'éléments surajoutés en couches, et inhibe le rotavirus dans des dosages de réduction de plaques. On peut utiliser ces compositions afin de prévenir et de traiter des infections rotavirales.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, GR, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991071554