Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1991008737) PHARMACOLOGICALLY ACTIVE AMIDE CARBOXYLATE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008737 International Application No.: PCT/GB1990/001941
Publication Date: 27.06.1991 International Filing Date: 12.12.1990
Chapter 2 Demand Filed: 05.06.1991
IPC:
A61K 31/16 (2006.01) ,C07C 233/47 (2006.01) ,C07C 233/49 (2006.01) ,C07C 233/51 (2006.01) ,C07C 235/12 (2006.01) ,C07C 259/06 (2006.01) ,C07C 323/59 (2006.01) ,C07C 323/60 (2006.01) ,C07D 239/38 (2006.01) ,C07D 277/30 (2006.01) ,C07D 307/91 (2006.01) ,C07D 333/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
47
having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
49
having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
51
having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
12
having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
259
Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04
without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
06
having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50
containing thio groups and carboxyl groups bound to the same carbon skeleton
51
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57
the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58
with amino groups bound to the carbon skeleton
59
with acylated amino groups bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50
containing thio groups and carboxyl groups bound to the same carbon skeleton
51
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60
with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
38
One sulfur atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
22
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
30
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
91
Dibenzofurans; Hydrogenated dibenzofurans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
26
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Hetero atoms other than halogen
34
Sulfur atoms
Applicants:
FISONS PLC [GB/GB]; Fison House Princes Street Ipswich Suffolk IP1 1QH, GB (AllExceptUS)
BENNION, Colin [GB/GB]; GB (UsOnly)
CONNOLLY, Stephen [GB/GB]; GB (UsOnly)
ROBINSON, David, Hulme [GB/GB]; GB (UsOnly)
Inventors:
BENNION, Colin; GB
CONNOLLY, Stephen; GB
ROBINSON, David, Hulme; GB
Agent:
JONES, Stephen, Anthony; Fisons Plc 12 Derby Road Loughborough Leicestershire LE11 OBB, GB
Priority Data:
8928456.616.12.1989GB
9023645.631.10.1990GB
Title (EN) PHARMACOLOGICALLY ACTIVE AMIDE CARBOXYLATE DERIVATIVES
(FR) DERIVES PHARMACOLOGIQUEMENT ACTIFS DE CARBOXYLATES D'AMIDES
Abstract:
(EN) This invention relates to compounds having pharmacological activity, processes for their preparation, compositions containing them and methods of treatment involving their use. In its broadest aspect, the invention is concerned with compounds, having general formula (I) in which R1 represents an alkyl C1-18 group optionally substituted by an aryl group or hydroxy or a cycloalkyl C3-6 group, R2 represents an alkyl C1-18 group optionally substituted by an aryl group, or R2 represents a group -CH2¿-X-R4 wherein X represents O or S, and R4 represents hydrogen, an aryl group, or an alkyl or alkenyl C¿1-18 group optionally substituted by an aryl group, R3 represents OH, alkoxy C1-6 or -NHR31, wherein R31 represents hydrogen, alkyl C1-6, OH or alkoxy C1-6 optionally substituted by an aryl group, R5 represents hydrogen, an aryl group or an alkyl or alkenyl C1-18 group optionally substituted by an aryl group, n represents 0, 1, 2 or 3, p represents 0, 1 or 2, q represents 0 or 1, Y represents -CHR6-, -CH=CH-, O or S, in which R6 represents hydrogen, an aryl group or an alkyl or alkenyl C1-18 group optionally substituted by an aryl group, and pharmaceutically acceptable derivates thereof.
(FR) La présente invention décrit des composés pharmacologiquement actifs, leurs procédés de fabrication, des compositions les renfermant et des méthodes de traitement dans lesquelles ils entrent. Sous son angle le plus large, la présente invention concerne des composés de formule générale (I), dans laquelle R1 représente un groupe alkyle ou alcényle C1-18 éventuellement substitué par un groupe aryle ou hydroxy ou cycloalkyle C3-6; R2 représente un groupe alkyle C1-18 éventuellement substitué par un groupe aryle, ou R2 représente un groupe -CH2-X-R4 dans lequel X représente 0 ou S, et R4 représente de l'hydrogène, un groupe aryle, ou un groupe alkyle ou alcényle C1-18 éventuellement substitué par un groupe aryle; R3 représente OH, un alcoxy C1-16 ou -NHR31, dans lequel R31 représente de l'hydrogène, un alkyle C1-6, OH ou un alcoxy C1-6 éventuellement substitué par un groupe aryle; R5 représente de l'hydrogène, un groupe aryle, alkyle, ou alcényle C1-18 éventuellement substitué par un groupe aryle; n représente 0, 1, 2 ou 3; p représente 0, 1 ou 2; q représente 0 ou 1; y représente un -CH=CH-, 0 ou S, dans lequel R6 représente de l'hydrogène, un groupe aryle ou un alkyle, ou encore un groupe alcényle C1-18 éventuellement substitué par un groupe aryle. On décrit également les dérivés pharmaceutiquement acceptables desdits composés.
Designated States: CA, FI, JP, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922720NO19922345EP0505467CA2072018