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1. (WO1991008716) METHOD OF TREATING THE ORAL CAVITY WITH DENTAL FLOSS CONTAINING CHEMOTHERAPEUTIC AGENTS
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WHAT IS CLAIMED IS:

1. A method of treating the oral cavity to alter local microbial ecology including: plaque formation, gingivitis and S . mutans count comprising treating the oral cavity with an interproximal delivery system comprising:

a) dental floss having from between two and 12 strands, each containing between about 100 and 800 filaments with a denier between 300 and about 1200, and

b) a cleaning preparation at from between 5 and about 100% by weight of said strands, wherein:

i. said filaments are substantially
free from sizing and binding
agents;
ii. said interproximal delivery system
splays upon being worked between
interproximal surfaces;
iii. said interproximal delivery system
release from between about 10 and
about 80% by weight of said
cleaning preparation upon
splaying; and
iv. said cleaning preparation:
a) is loaded into said delivery
system as a substantially
aqueous free, hot-melt
emulsion,
b) is contained throughout the
interproximal delivery
system, primarily in the area surrounding said filaments
with less than about 5% by
weight of said cleaning
preparation on the outermost
surface of said delivery
system, and
c) can contain up to about 50%
by weight of an active
chemotherapeutic agent
selected from the group
consisting of:
antimicrobials, antibiotics,
antioxidants, desensitizers,
and anti-tartar agents.

2. The method of Claim 1, wherein the floss contains an ingestible, oral hygiene cleaning
preparation comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate,
coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and
polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters,
propoxylated cetyl alcohol,
block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight,
soap powder,

and mixtures thereof, and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers,
polydimethyl siloxane,
normal paraffins having a chain length of 16
carbon atoms or greater, and
paraffins with several loci of branching and
unsaturation and carbowaxes.

3. A method of releasing interproximally, supragingivally and subgingivally a chemotherapeutic preparation from a dental floss containing an
ingestible, oral hygiene cleaning preparation
comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate,
coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and
polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters, propoxylated cetyl alcohol.

block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a
hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight,
soap powder,

and mixtures thereof; and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers,
polydimethyl siloxane,
long chain hydrocarbons,
normal paraffins having a chain length of 16
carbon atoms or greater,
paraffins with several loci of branching and
unsaturation
carbowaxes, and

c. a chemotherapeutic agent selected from the group consisting of antimicrobials, antibiotics, antioxidants, desensitizers and anti-tartar agents, at a concentration from between about 0.5% and about 3.0% by weight of said preparation.

4. The method of Claim 1, wherein the floss further contains a powder substance separate from said preparation selected from the group consisting of abrasives, gums, viscosity control agents, polyols and mixtures thereof.

5. The method of Claim 1, wherein the cleaning preparation is loaded into the floss at a rate between about 20 and about 50 mg/yd and wherein said
preparation releases at a rate between about 30% and about 70% by weight of the load.

6. The method of Claim 1, wherein the cleaning preparation is loaded into the floss at a rate between about 10 mg/yd and about 100 mg/yd.

7. The method of Claim 1, wherein the cleaning preparation contains an abrasive selected from the group consisting of silica, calcium carbonate, talc, dicalcium phosphate and mixtures thereof.

8. The method of Claim 1, wherein the cleaning preparation contains a desensitizer.

9. The method of Claim 1, wherein the cleaning preparation contains an anti-oxidant.

10. A method of treating dental fillings including interproximal restorations, which comprises flossing with a dental floss containing an ingestible, oral hygiene cleaning preparation containing an active chemotherapeutic agent, said cleaning preparation comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate,
coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters,
propoxylated cetyl alcohol,
block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a
hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight,
soap powder,

and mixtures thereof; and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers,
polydimethyl siloxane,
long chain hydrocarbons,
normal paraffins having a chain length of 16
carbon atoms or greater,
paraffins with several loci of branching and
unsaturation
carbowaxes, and

and
c. an active chemotherapeutic agent selected from the group consisting of tetracycline, chlorhexidine, stannous fluoride, sodium fluoride, and polyvinyl pyrrolidone iodine complex (PVPI), at a concentration from between about 0.5% to about 10.0% by weight of said preparation.

11. A method of treating caries in radiotherapy patients comprising flossing with a dental floss containing an ingestible, oral hygiene cleaning
preparation containing an active chemotherapeutic agent, said cleaning preparation comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate,
coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and
polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters,
propoxylated cetyl alcohol,
block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a
hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight,
soap powder,

and mixtures thereof; and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers,
polydimethyl siloxane,
long chain hydrocarbons,
normal paraffins having a chain length of 16
carbon atoms or greater,
paraffins with several loci of branching and unsaturation
carbowaxes, and

and
c. an active chemotherapeutic agent selected from the group consisting of tetracycline, chlorhexidine, stannous fluoride, sodium fluoride, and polyvinyl pyrrolidone iodine complex (PVPI), at a concentration from between about 0.5% to about 10.0% by weight of said preparation.

12. A method of treating periodontitis comprising flossing with a dental floss containing an ingestible, oral hygiene cleaning preparation containing an active chemotherapeutic agent, said cleaning preparation comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate,
coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and
polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters,
propoxylated cetyl alcohol,
block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a
hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight, soap powder,

and mixtures thereof; and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers,
polydimethyl siloxane,
long chain hydrocarbons,
normal paraffins having a chain length of 16
carbon atoms or greater,
paraffins with several loci of branching and
unsaturation
carbowaxes, and

and
c. an active chemotherapeutic agent selected from the group consisting of tetracycline, chlorhexidine, stannous fluoride, sodium fluoride, and polyvinyl pyrrolidone iodine complex (PVPI), at a concentration from between about 0.5% to about 10.0% by weight of said preparation.

13. A method of pretreating oral surgery patients comprising flossing prior to surgery with a dental floss containing an ingestible, oral hygiene cleaning preparation containing an active chemotherapeutic agent, said cleaning preparation comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate, coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and
polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters,
propoxylated cetyl alcohol,
block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a
hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight,
soap powder,

and mixtures thereof; and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers,
polydimethyl siloxane,
long chain hydrocarbons,
normal paraffins having a chain length of 16
carbon atoms or greater,
paraffins with several loci of branching and
unsaturation
carbowaxes, and

and
c. an active chemotherapeutic agent selected from the group consisting of tetracycline, chlorhexidine, stannous fluoride, sodium fluoride, and polyvinyl pyrrolidone iodine complex (PVPI), at a concentration from between about 0.5% to about 10.0% by weight of said preparation.

14. A method of post-treating oral surgery
patients comprising flossing after surgery with a dental floss containing an ingestible, oral hygiene cleaning preparation containing an active
chemotherapeutic agent, said cleaning preparation comprising:
a. a surfactant selected from the group
consisting of:
sodium lauryl sulfate,
sodium lauroyl sarcosinate,
polyethylene glycol stearate,
polyethylene glycol monostearate,
coconut monoglyceride sulfonates,
sodium alkyl sulfate,
sodium alkyl sulfoacetates,
block copolymers of polyoxyethylene and
polyoxypropylene,
allylpolyglycol ether carboxylates,
polyethylene derivatives of sorbitan esters,
propoxylated cetyl alcohol,
block copolymers comprising a cogeneric
mixture of conjugated polyoxypropylene
and polyoxylethylene compound having as a
hydrophobe a polyoxypropylene polymer of
at least 1200 molecular weight,
soap powder,

and mixtures thereof; and

b. a coating substance insoluble in said
surfactant selected from the group consisting of:
silicones,
silicone glycol copolymers, polydimethyl siloxane,
long chain hydrocarbons,
normal paraffins having a chain length of 16
carbon atoms or greater,
paraffins with several loci of branching and
unsaturation
carbowaxes, and

and
c. an active chemotherapeutic agent selected from the group consisting of tetracycline, chlorhexidine, stannous fluoride, sodium fluoride, and polyvinyl pyrrolidone iodine complex (PVPI), at a concentration from between about 0.5% to about 10.0% by weight of said preparation.