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1. (WO1991008478) METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008478 International Application No.: PCT/US1990/007015
Publication Date: 13.06.1991 International Filing Date: 30.11.1990
Chapter 2 Demand Filed: 24.06.1991
IPC:
C07K 7/02 (2006.01) ,C07K 14/78 (2006.01) ,C07K 16/18 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02
Linear peptides containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
WASHINGTON RESEARCH FOUNDATION [US/US]; 4225 Roosevelt Way N.E. Seattle, WA 98105, US (AllExceptUS)
EYRE, David, R. [GB/US]; US (UsOnly)
Inventors:
EYRE, David, R.; US
Agent:
COOK, Robert, R. ; Christensen, O'Connor, Johnson & Kindness 2800 Pacific First Centre 1420 Fifth Avenue Seattle, WA 98101, US
Priority Data:
444,88101.12.1989US
614,71921.11.1990US
Title (EN) METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO)
(FR) PROCEDE DE DETECTION DE LA DEGRADATION DE COLLAGENE IN VIVO
Abstract:
(EN) Methods of determining collagen degradation $i(in vivo), by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.
(FR) Procédés de détermination de la dégradation de collagène in vivo, consistant à quantifier la concentration d'un peptide dans un fluide biologique, le peptide étant un télopeptide de collagène de type II à terminaison C contenant un réticule de pyridinoline d'hydroxylysyle, ou un télopeptide de collagène de type III contenant un réticule de pyridinoline d'hydroxylysyle. Les procédés appropriés comprennent des analyses immunométriques, des analyses fluorométriques, ainsi que des titrations électrochimiques de quantification. Les structures de peptides spécifiques présentant des réticules ainsi que des matériels de quantification de ces peptides dans un fluide biologique sont décrits.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19922149EP0502928RU02139541AU1991068898