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1. (WO1991008313) ANTISENSE OLIGONUCLEOTIDE INHIBITION OF PAPILLOMAVIRUS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008313 International Application No.: PCT/US1990/007067
Publication Date: 13.06.1991 International Filing Date: 03.12.1990
Chapter 2 Demand Filed: 01.07.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/025 (2006.01) ,C12N 15/11 (2006.01) ,C12Q 1/68 (2006.01) ,C12Q 1/70 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
025
Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
ISIS PHARMACEUTICALS, INC. [US/US]; 2280 Faraday Avenue Carlsbad, CA 92008, US (AllExceptUS)
CROOKE, Stanley, T. [US/US]; US (UsOnly)
MIRABELLI, Christopher, K. [US/US]; US (UsOnly)
ECKER, David, J. [US/US]; US (UsOnly)
COWSERT, Lex, M. [US/US]; US (UsOnly)
Inventors:
CROOKE, Stanley, T.; US
MIRABELLI, Christopher, K.; US
ECKER, David, J.; US
COWSERT, Lex, M.; US
Agent:
CALDWELL, John, C. ; Woodcock Washburn Kurtz Mackiewicz & Norris 46th floor One Liberty Place Philadelphia, PA 19103, US
Priority Data:
445,19604.12.1989US
Title (EN) ANTISENSE OLIGONUCLEOTIDE INHIBITION OF PAPILLOMAVIRUS
(FR) INHIBITEURS OLIGONUCLEOTIDIQUES NON CODANTS DU VIRUS DU PAPILLOME
Abstract:
(EN) Oligonucleotides and oligonucleotide analogs are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide or oligonucleotide analog is provided which is hybridizable with a messenger RNA from a papillomavirus. The oligonucleotide or oligonucleotide analog is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E1, E7, or E6-7 messenger RNAs.
(FR) Oligonucléotides et analogues oligonucléotidiques pouvant avoir une action réciproque non codante avec l'ARN messager du virus du papillome. De tels oligonucléotides ou analogues oligonucléotidiques peuvent servir au diagnostic et à la thérapeutique ainsi qu'à des fins de recherche. Selon des modes de réalisation préférés, l'oligonucléotide ou l'analogue oligonucléotidique est hybridable avec un ARN messager provenant d'un virus du papillome, peut inhiber la fonction de l'ARN, et est donc utile à la thérapie des infections provoquées par un tel virus du papillome. Selon un mode de réalisation préféré, on cible des parties du virus du papillome pour une attaque non codante. On peut donc obtenir les oligonucléotides préférables, c'est-à-dire ceux qui s'hybrident avec les ARN messagers E2, E1, E7, ou E6-7.
Designated States: AU, BR, CA, FI, HU, JP, KR, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922593NO19922169EP0503002JPH05501058CA2070664KR1019960012069*
AU1991071756