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1. (WO1991008309) METHODS FOR DETECTION OF NEURODEGENERATIVE DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008309 International Application No.: PCT/US1990/007116
Publication Date: 13.06.1991 International Filing Date: 05.12.1990
Chapter 2 Demand Filed: 03.07.1991
IPC:
C12Q 1/68 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. [US/US]; 750 Washington Street, Box 817 Boston, MA 02111, US
TUFTS UNIVERSITY [US/US]; Medford, MA 02155, US
Inventors:
TALAMO, Barbara, R.; US
KAUER, John, S.; US
Agent:
CLARK, Paul, T.; Fish & Richardson One Financial Center Suite 2500 Boston, MA 02111-2658, US
Priority Data:
446,08705.12.1989US
Title (EN) METHODS FOR DETECTION OF NEURODEGENERATIVE DISEASE
(FR) METHODES DE DETECTION DE MALADIES NEURODEGENERATIVES
Abstract:
(EN) Methods for the detection of neurodegenerative disease in a living mammal. Methods include obtaining a sample including olfactory receptor epithelium from the nasal passage of the mammal and analyzing the sample for the presence of neurodegenerative disease. Methods of analysis include polymerase chain amplification of a selected nucleic acid sequence and subsequent detection of the amplified sequence as well as the detection of antigens via antigen-antibody interaction wherein presence of antigens and/or nucleic acid sequence is indicative of the neurodegenerative disease.
(FR) Méthodes de détection de maladies neurodégénératives chez un mammifère vivant. Les méthodes comprennent l'obtention d'un prélèvement comprenant de l'épithélium récepteur olfactif depuis le passage nasal du mammifère et l'analyse du prélèvement pour déceler la présence d'une maladie neurodégénérative. Les méthodes d'analyse comprennent l'amplification de la chaîne de polymérase d'une séquence d'acide nucléique sélectionnée et la détection ultérieure de la séquence amplifiée aussi bien que la détection d'antigènes par l'intermédiaire d'un antigène-anticorps selon laquelle la présence d'antigènes et/ou de la séquence d'acide nucléique indique la présence d'une maladie neurodégénérative.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)