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1. (WO1991008306) POLYMORPHISM OF HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIB AND DIAGNOSTIC AND THERAPEUTIC APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008306 International Application No.: PCT/US1990/004452
Publication Date: 13.06.1991 International Filing Date: 14.08.1990
Chapter 2 Demand Filed: 06.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/705 (2006.01) ,C07K 16/28 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
THE BLOOD CENTER OF SOUTHEASTERN WISCONSIN, INC. [US/US]; 1701 West Wisconsin Avenue Milwaukee, WI 53233, US
Inventors:
NEWMAN, Peter, J.; US
ASTER, Richard, H.; US
Agent:
BENT, Stephen, A. ; Foley & Lardner, Schwartz, Jeffery, Schwaab, Mack, Blumenthal & Evans 1800 Diagonal Road Suite 510 Alexandria, VA 22313, US
Priority Data:
443,94601.12.1989US
Title (EN) POLYMORPHISM OF HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIB AND DIAGNOSTIC AND THERAPEUTIC APPLICATIONS THEREOF
(FR) POLYMORPHISME DE GLYCOPROTEINE IIB DE MEMBRANE PLAQUETTAIRE HUMAINE ET SES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
Abstract:
(EN) Isolated polynucleotide molecules and peptides encoded by these molecules can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications, relating to human platelet Bak polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from platelet mRNA, it is possible to type glycoprotein GPIIb with regard to the Bak polymorphism, for example, in the contect of diagnosing and treating clinical syndromes associated with GPIIb-related immune responses.
(FR) On peut utiliser des molécules de polynucléotides isolées ainsi que des peptides codés par ces molécules dans l'analyse de phénotypes d'alloantigènes, ainsi que dans des applications diagnostiques et thérapeutiques, en rapport avec le polymorphisme Bak de plaquettes humaines. Par l'analyse d'ADN génomique ou d'ADN génomique amplifié, ou d'ADN complémentaire amplifié dérivé d'ARN messager plaquettaire, il est possible de typer la GPIIb glycoprotéique par rapport au polymorphisme Bak, par exemple, dans le contexte de diagnostics de traitement de syndromes cliniques associés à des réponses immunes en rapport avec la GPIIb.
Designated States: AU, CA, JP, KR
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1990062768