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1. (WO1991008297) METHODS AND MATERIALS FOR EXPRESSION OF HUMAN PLASMINOGEN VARIANT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008297 International Application No.: PCT/US1990/006345
Publication Date: 13.06.1991 International Filing Date: 31.10.1990
Chapter 2 Demand Filed: 23.04.1991
IPC:
A61K 38/00 (2006.01) ,A61K 38/54 (2006.01) ,C07K 14/315 (2006.01) ,C12N 9/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
54
Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44-A61K38/46 or A61K38/51-A61K38/53186
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
315
from Streptococcus (G), e.g. Enterococci
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
68
Plasmin, i.e. fibrinolysin
Applicants:
GENENTECH, INC. [US/US]; 460 Point San Bruno Boulevard South San Francisco, CA 94080, US
Inventors:
CASTELLINO, Francis, J.; US
HIGGINS, Deborah, L.; US
Agent:
HASAK, Janet, E. ; Genentech, Inc. Legal Department 460 Point San Bruno Boulevard South San Francisco, CA 94080, US
ARMITAGE, Ian, M.; Mewburn Ellis & Co. York House 23 Kingway London WC2B 6HP, GB
Priority Data:
444,58401.12.1989US
Title (EN) METHODS AND MATERIALS FOR EXPRESSION OF HUMAN PLASMINOGEN VARIANT
(FR) PROCEDES ET MATIERES D'EXPRESSION DE VARIANTE DE PLASMINOGENE HUMAIN
Abstract:
(EN) A cleavage-resistant plasminogen molecule is provided that is conveniently produced in recombinant cells by expression of a nucleic acid sequence encoding the plasminogen molecule. Preferably the plasminogen is a sequence variant with a modification in its two-chain cleavage site. The plasminogen molecule may be purified, acylated, complexed with acylated or non-acylated fibrinolytic enzymes, and formulated into pharmaceutical compositions for use in thrombolytic therapy.
(FR) Est décrite une molécule de plasminogène résistant au clivage, produite de manière appropriée dans des cellules recombinées par expression d'une séquence d'acide nucléique codant la molécule de plasminogène. On peut purifier la molécule de plasminogène, l'acyler, la transformer en complexe à l'aide d'enzymes fibrinolytiques acylées ou non acylées, et à formuler en compositions pharmaceutiques utilisées en thérapie thrombolytique.
Designated States: AU, BG, CA, HU, JP, RO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0502872CA2072649AU1990067212