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1. (WO1991008233) NEW BLOOD-CLOT-DISSOLVING PROTEINS, AND THEIR PREPARATION FROM THE LEECH HIRUDO MEDICINALIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008233 International Application No.: PCT/EP1990/001996
Publication Date: 13.06.1991 International Filing Date: 22.11.1990
Chapter 2 Demand Filed: 27.12.1990
IPC:
A61K 38/00 (2006.01) ,C12N 9/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
Applicants:
BASF AKTIENGESELLSCHAFT [DE/DE]; Carl-Bosch-Strasse 38 D-67056 Ludwigshafen, DE (AllExceptUS)
MEYER, Thomas [DE/DE]; DE (UsOnly)
FRIEDRICH, Thomas [DE/DE]; DE (UsOnly)
KOERWER, Wolfgang [DE/DE]; DE (UsOnly)
STRUBE, Karl-Hermann [DE/DE]; DE (UsOnly)
BIALOJAN, Siegfried [DE/DE]; DE (UsOnly)
Inventors:
MEYER, Thomas; DE
FRIEDRICH, Thomas; DE
KOERWER, Wolfgang; DE
STRUBE, Karl-Hermann; DE
BIALOJAN, Siegfried; DE
Priority Data:
P 39 39 801.301.12.1989DE
Title (DE) NEUE BLUTGERINNSELAUFLÖSENDE PROTEINE UND IHRE HERSTELLUNG AUS DEM BLUTEGEL HIRUDO MEDICINALIS
(EN) NEW BLOOD-CLOT-DISSOLVING PROTEINS, AND THEIR PREPARATION FROM THE LEECH HIRUDO MEDICINALIS
(FR) NOUVELLES PROTEINES DISSOLVANT LES CAILLOTS SANGUINS, ET LEUR PREPARATION A PARTIR DE LA SANGSUE HIRUDO MEDICINALIS
Abstract:
(DE) Blutgerinnselauflösendes Protein aus dem Blutegel Hirudo Medicinalis, welches die im Sequenzprotokoll aufgeführten Sequenzen 1 bis 13 enthält und $g(e)-($g(g)-glutamyl)-lysin-Bindungen spaltet, sowie dessen Muteine und natürliche Varianten mit einer vergleichbaren Wirkung.
(EN) Described is a protein which dissolves blood clots, prepared fromthe leech Hirudo Medicinalis, containing the sequences 1-13 listed in the sequence protocoland capable of splitting $g(e)-($g(a)-glutamyl)-lysine compounds, plus its muteins and natural variants with a comparable action.
(FR) Protéine dissolvant les caillots sanguins, préparée à partir de la sangsue Hirudo medicinalis, contenant les séquences 1 à 13 indiquées dans le protocole de séquences et dissociant les liaisons $g(e)-($g(g)-glutamyl)-lysine, ainsi que les mutéines et les variantes naturelles de cette protéine ayant un effet comparable.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
EP0502876CA2065258