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1. (WO1991008230) VERSICAN CORE PROTEIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008230 International Application No.: PCT/US1990/006897
Publication Date: 13.06.1991 International Filing Date: 27.11.1990
Chapter 2 Demand Filed: 27.06.1991
IPC:
C07K 14/78 (2006.01) ,C07K 16/18 (2006.01) ,G01N 33/53 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
LA JOLLA CANCER RESEARCH FOUNDATION [US/US]; 10901 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
RUOSLAHTI, Erkki, I.; US
Agent:
CAMPBELL, Cathryn ; Pretty, Schroeder, Brueggemann & Clark 444 South Flower Street Suite 2000 Los Angeles, CA 90071, US
Priority Data:
441,17927.11.1989US
Title (EN) VERSICAN CORE PROTEIN
(FR) PROTEINE NUCLEAIRE DU VERSICANE
Abstract:
(EN) The invention relates to the fibroblast proteoglycan, versican. The versican core protein has the amino acid sequence, and is encoded by the nucleotide sequence, as shown in Figure 1. The nucleotide sequence encoding the hyaluronic acid binding domain is provided and methods of preparing recombinant proteins having hyaluronic acid binding activity are provided. Such protein can be used to determine the presence of hyaluronic acid and as a vehicle to bring other molecules in contact with hyaluronic acid. The complete versican sequence will allow the production of the entire versican molecule to be used, for example, in tissue reconstruction. Nucleic acid probes are provided which are useful for detecting nucleic acid sequences encoding versican. The invention also provides antibodies reactive with versican.
(FR) L'invention concerne le protéoglycane du fibroblaste, notamment le versicane. La protéine nucléaire du versicane possède la séquence d'acides aminés et est codé par la séquence de nucléotides illustrées à la figure 1. La séquence nucléaire qui code pour le domaine de liaison à l'acide hyaluronique est décrite ainsi que les méthodes de préparation de protéines recombinantes à activité de liaison à l'acide hyaluronique. Lesdites protéines peuvent être utilisées pour déterminer la présence de l'acide hyaluronique et comme véhicule pour amener d'autres molécules en contact avec l'acide hyaluronique. La séquence complète du versicane permettra de produire la molécule entière du versicane, qui peut être utilisée par exemple pour la reconstruction des tissus. On décrit des sondes d'acide nucléiques qui sont utiles pour la détection des séquences d'acide nucléique codant pour le versicane. L'invention concerne également des anticorps capables de réagir avec le versicane.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991069145