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1. (WO1991008225) HEXAPEPTIDES WITH SULPHATE ESTER GROUPS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008225 International Application No.: PCT/US1990/006739
Publication Date: 13.06.1991 International Filing Date: 16.11.1990
Chapter 2 Demand Filed: 11.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/595 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
595
Gastrins; Cholecystokinins (CCK)
Applicants:
FISONS CORPORATION [US/US]; 755 Jefferson Road Rochester, NY 14623, US (AllExceptUS)
ROSAMOND, James, Donald [US/US]; US (UsOnly)
Inventors:
ROSAMOND, James, Donald; US
Agent:
GOLDBERG, Jules, E.; McAulay Fisher Nissen Goldberg & Kiel 261 Madison Avenue New York, NY 10016, US
Priority Data:
441,27527.11.1989US
Title (EN) HEXAPEPTIDES WITH SULPHATE ESTER GROUPS
(FR) HEXAPEPTIDES DOTES DE GROUPES D'ESTERS DE SULFATE
Abstract:
(EN) Compounds of formula (I), wherein M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; G is Gly, DAla, Pro, Ala, $g(b)Ala or Sar; W is Trp, MeTrp, Ala or Nal; X is Met, MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; J is Asp, DAsp, MeAsp, Ala or Asn; F1 is (S)-NH, (R)-NH, (S)-R1N or (R)-R2N; F2 is H, Cl, I, Br, F, NO2, NH2, R3 or OR4; Z is NH2, NHR5 or NR5R6; R1, R2, R3, R5 and R6 are C1 to 6 alkyl; and R4 is H or C1 to 6 alkyl, and pharmaceutically acceptable salts thereof, are new and useful as pharmaceuticals. In particular they are useful for the treatment of obesity and for stimulating contraction of the gall bladder.
(FR) Les composés de la formule (I), dans laquelle M représente Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala ou Ly; G représente Gly, DAla, Pro, Ala, $g(b)Ala ou Sar; W représente Trp, MeTrp, Ala ou Nal; X représente Met, MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala ou Lys; J représente Asp, DAsp, MeAsp, Ala ou Asn; F1 représente (S)-NH, (R)-NH, (S)-R1N ou (R)-R2N; F2 représente H, Cl, I, Br, F, NO2, NH2, R3 ou OR4; Z représente NH2, NHR5 ou NR5R6; R1, R2, R3, R5 et R6 représente alkyle contenant 1 à 6 atomes de carbone; et R4 représente H ou alkyle contenant 1 à 6 atomes de carbone; ainsi que leurs sels pharmaceutiquement acceptables, constituent des produits pharmaceutiques nouveaux et utiles. Ils sont notamment utiles dans le traitement de l'obésité, et dans la stimulation de la contraction de la vésicule biliaire.
Designated States: AU, FI, JP, KR, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922404NO19922094IL96465EP0495013JPH05500962DE000069017704
PT95996AU1991069644DK0495013