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1. (WO1991008217) HUMAN INTESTINAL MUCINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008217 International Application No.: PCT/US1990/007087
Publication Date: 13.06.1991 International Filing Date: 04.12.1990
Chapter 2 Demand Filed: 01.07.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01) ,C07K 16/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 300 Lakeside Drive 22nd Floor Oakland, CA 94612-3550, US
Inventors:
KIM, Young, S.; US
GUM, James, R., Jr.; US
Agent:
CHING, Edwin, P.; Townsend and Townsend One Market Plaza 2000 Steuart Tower San Francisco, CA 94105, US
Priority Data:
447,14005.12.1989US
Title (EN) HUMAN INTESTINAL MUCINS
(FR) MUCINES INTESTINALES HUMAINES
Abstract:
(EN) DNA sequences encoding part of the polypeptide sequences of human intestinal mucins (HIM) have been isolated and characterized. These sequences may be expressed in procaryotes to produce unglycosylated HIM polypeptides or eucaryotes to produce glycosylated versions, all of which are suitable for raising antibodies and other uses. Moreover, the DNA has been used to characterize expression and genomic organization of the HIM gene family. Reagents based on these discoveries provide means for diagnosis and treatment of various biological disorders, such as cystic fibrosis and colon cancers.
(FR) On a isolé et caractérisé des séquences d'ADN codant une partie des séquences polypeptidiques des mucines intestinales humaines (HIM). Ces séquences peuvent être exprimées dans des procaryotes afin de produire des polypeptides non glycosylés de HIM, ou dans des eucaryotes afin d'en produire des versions glycosylées, dont la totalité est adaptée à la croissance des anticorps et à d'autres utilisations. Par ailleurs, on a utilisé l'ADN pour caractériser l'expression et l'organisation génomique de la famille des gènes de HIM. On peut utiliser des réactifs à base de ces découvertes pour diagnostiquer et traiter divers troubles biologiques, tels que la mucoviscidose et le cancer du côlon.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)