Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1991008215) PROCESS FOR THE PREPARATION OF 2-AMINO-9-(2,3,5-TRI-0-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE AND NOVEL INTERMEDIATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008215 International Application No.: PCT/US1990/007004
Publication Date: 13.06.1991 International Filing Date: 30.11.1990
IPC:
C07H 19/16 (2006.01) ,C07H 19/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
Applicants:
ASH STEVENS, INC. [US/US]; 5861 John C. Lodge Freeway Detroit, MI 48202-3398, US
Inventors:
BLUMBERGS, Peter; US
KHAN, Mohammed, S.; US
KALAMAS, Richard L.; US
Agent:
McLEOD, Ian, C.; 2190 Commons Parkway Okemos, MI 48864, US
Priority Data:
445,44604.12.1989US
Title (EN) PROCESS FOR THE PREPARATION OF 2-AMINO-9-(2,3,5-TRI-0-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE AND NOVEL INTERMEDIATES
(FR) PROCEDE DE PREPARATION DE 2-AMINO-9-(2,3,5-TRI-0-BENZYLE BETA-D-ARABINOFURANOSYLE)ADENINE ET NOUVEAUX PRODUITS INTERMEDIAIRES
Abstract:
(EN) A process for the preparation of 2,6-diamino-9-(2,3,5-tri-0-benzyl-beta-D-arabinofuranosyl purine (V) by reacting 2,6-di(alkoxyacetamido)purine (II) with 2,3,5-tri-0-benzyl-1-chloro-alpha-D-arabinofuranose (III) to produce 2,6-di(alkoxyacetamido)-9-(2,3,5-tri-0-benzyl-beta-D-arabinofuranosyl)purine (IV) and then deprotecting the 2,6-positions to produce the 2,6-diamine (V) is described. The process provides purine (V) in high yield. Purine (V) is an intermediate in the preparation of 9-beta-D-arabinofuranosyl-2-fluoroadenine which is a cytotoxic agent.
(FR) On décrit un procédé de préparation de 2,6-diamino-9-(2,3,5-tri-0-benzyl-béta-D-arabinofuranosyle purine (V) consistant à faire réagir de la 2,6-di(alcoxyacétamido)purine (II) avec de la 2,3,5-tri-0-benzyle-1-chloro-alpha-D-arabinofuranose (III) de façon à produire de la 2,6-di(alcoxyacétamido)-9-(2,3,5-tri-0-benzyl-bêta-D-arabinofuranosyle)purine (IV), et à supprimer ensuite la protection des positions 2,6 afin de produire de la damine-2,6 (V). Le procédé fournit de la purine (V) en grande quantité. La purine (V) est un produit intermédiaire dans la préparation de 9-bêta-D-arabinofuranosyle-2-fluoroadénine qui est un agent cytotoxique.
Designated States: JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0456817JPH04504268