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1. (WO1991008208) HETEROCYCLIC SUBSTITUTED NAPHTHYRIDINONES AND METHODS AND COMPOSITIONS EMPLOYING THEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008208 International Application No.: PCT/US1990/006873
Publication Date: 13.06.1991 International Filing Date: 30.11.1990
Chapter 2 Demand Filed: 01.07.1991
IPC:
C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road Kenilworth, NJ 07033, US (AllExceptUS)
BLYTHIN, David, J. [GB/US]; US (UsOnly)
Inventors:
BLYTHIN, David, J.; US
Agent:
BOXER, Matthew ; Schering-Plough Corporation One Giralda Farms Madison, NJ 07940-1000, US
Priority Data:
445,58704.12.1989US
Title (EN) HETEROCYCLIC SUBSTITUTED NAPHTHYRIDINONES AND METHODS AND COMPOSITIONS EMPLOYING THEM
(FR) NAPHTYRIDINONES SUBSTITUEES HETEROCYCLIQUES, PROCEDES ET COMPOSITIONS LES EMPLOYANT
Abstract:
(EN) Nitrogen-containing heterocyclic substituted naphthyridinones of formula (I), effective in treating allergic reactions, inflammation, inflammatory bowel disease, pepticulcers and hyperproliferative skin disease, and pharmaceutical compositions employing them, are disclosed. Formula (I) or a pharmaceutically acceptable salt thereof, wherein: A is O or S; W represents (a) or (b); R represents H or alkyl; R1 represents alkanediyl; R2 represents a covalent bond or -alkanediyl-O-; R3 represents alkyl, cycloalkyl, benzyl, substituted benzyl or hydroxyalkyl; Q represents phenyl, 1- or 2-naphthyl, 1-,2-,3-,4-,5-,6-, or 7-indenyl or 1-,2-,3-,4-,5-,6- or 7-indanyl, each of which may optionally be substituted with 1 to 3 Y groups as defined below; and each Y is independently selected from alkyl, halo, nitro, alkoxy, alkylthio, -CF3, -CN, cycloalkyl, alkylsulfinyl or alkylsulfonyl.
(FR) Sont décrites des naphtyridinones substituées hétérocycliques contenant de l'azote de la formule (I), efficaces dans le traitement de réactions allergiques, d'inflammations, d'affections intestinales inflammatoires, d'ulcères gastro-duodénaux et de maladies hyperprolifératives de la peau, ainsi que des compositions pharmaceutiques les employant, ou un sel pharmaceutiquement acceptable de ladite formule, dans laquelle: A représente O ou S; W représente (a) ou (b); R représente H ou alkyle; R1 représente alcanediyle; R2 représente une liaison covalente ou -alcanediyle-O-; R3 représente alkyle, cycloalkyle, benzyle, benzyle ou hydroxyalkyle substitué, benzyle ou hydroxyalkyle substitué, Q représente phényle, 1- ou 2- naphthyle, 1-, 2-, 3-, 4-, 5-, 6-, ou 7-indényle ou 1-, 2-, 3-, 4-, 5-, 6- ou 7- indanyle, dont chacun peut être facultativement remplacé par 1 à 3 groupes Y ci-dessous définis; et chaque Y est indépendamment choisi parmi alkyle, halo, nitro, alkoxy, alkylthio, -CF3, -CN, cycloalkyle, alkylsulfinyle ou alkylesulfonyle.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0505434US5760034JPH04506357CA2070400AU1991069603