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1. (WO1991008205) N-ACYL-SUBSTITUTED AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008205 International Application No.: PCT/EP1990/001961
Publication Date: 13.06.1991 International Filing Date: 14.11.1990
Chapter 2 Demand Filed: 27.05.1991
IPC:
C07D 401/06 (2006.01) ,C07D 495/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
DR. LO. ZAMBELETTI S.P.A. [IT/IT]; Via Zambeletti I-20021 Baranzate, IT (AllExceptUS)
VECCHIETTI, Vittorio [IT/IT]; IT (UsOnly)
COLLE, Roberto [IT/IT]; IT (UsOnly)
Inventors:
VECCHIETTI, Vittorio; IT
COLLE, Roberto; IT
Agent:
RUSSELL, Brian, John ; SmithKline Beecham, Corporate Patents Great Burgh Yew Tree Bottom Road Epsom Surrey KT18 5XQ, GB
Priority Data:
8926560.724.11.1989GB
Title (EN) N-ACYL-SUBSTITUTED AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS
(FR) COMPOSES AZACYCLIQUES A SUBSTITUTION N-ACYLE, PROCEDES DE PREPARATION DE CES COMPOSES ET UTILISATION DE CES COMPOSES COMME PHARMACEUTIQUES
Abstract:
(EN) A compound, or a solvate or salt thereof, of formula (I), in which: (A) is ($g(a)) or ($g(b)); p is 1, 2 or 3; ROC- is an acyl group linked to the nitrogen atom of group (A) in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring; R1 and R2 are substituents on the same or different carbon atoms and are independently hydrogen or C1-6 alkyl; and Ra is a fused substituted or unsubstituted heterocyclic or carbocyclic aromatic ring, is useful for the treatment of pain, hyponatraemic disease states or cerebral ischaemia.
(FR) L'invention se rapporte à un composé, ou à un solvant ou à un sel de ce composé, qui est réprésenté par la formule (I), dans laquelle: (A) représente ($g(a)) ou ($g(b)), p est égal à 1, à 2 ou à 3; ROC- représente un groupe acyle relié à l'atome d'azote du groupe (A) dans lequel le groupe (R) contient une chaîne fermée aromatique carbocyclique ou aromatique hétérocyclique substituée ou non substituée; R1 and R2 sont des substituants placés sur les mêmes atomes de carbone ou sur des atomes de carbone différents et représentent séparément l'hydrogène ou un alkyle C1-6; et Ra représente une chaîne fermée aromatique hétérocyclique ou carbocyclique substituée ou non substituée. De tels composés sont utiles pour le traitement de la douleur, d'états d'affection hyponatrémique ou de l'ischémie cérébrale.
Designated States: JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0502015US5366981JPH05503688