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1. (WO1991008203) NOVEL THIAZOLIDINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/008203 International Application No.: PCT/HU1990/000077
Publication Date: 13.06.1991 International Filing Date: 23.11.1990
IPC:
C07D 277/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
12
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Oxygen atoms
Applicants:
RICHTER GEDEON VEGYÉSZETI GYÁR RT. [HU/HU]; Gyömro^"i u. 19-21 H-Budapest X, HU (AllExceptUS)
SZABADKAI, István [HU/HU]; HU (UsOnly)
HARSÁNYI, Kálmán [HU/HU]; HU (UsOnly)
SZABÓ, Zsoltné [HU/HU]; HU (UsOnly)
HEGEDÜS, Béla [HU/HU]; HU (UsOnly)
EZER, Elemér [HU/HU]; HU (UsOnly)
MATÚZ, Judit [HU/HU]; HU (UsOnly)
SZPORNY, László [HU/HU]; HU (UsOnly)
SÁGHY, Katalin [HU/HU]; HU (UsOnly)
HAJÓS, György [HU/HU]; HU (UsOnly)
CSEHI, Attila [HU/HU]; HU (UsOnly)
BALOGH, Gábor [HU/HU]; HU (UsOnly)
Inventors:
SZABADKAI, István; HU
HARSÁNYI, Kálmán; HU
SZABÓ, Zsoltné; HU
HEGEDÜS, Béla; HU
EZER, Elemér; HU
MATÚZ, Judit; HU
SZPORNY, László; HU
SÁGHY, Katalin; HU
HAJÓS, György; HU
CSEHI, Attila; HU
BALOGH, Gábor; HU
Agent:
DANUBIA PATENT & TRADE MARK ATTORNEYS; Bajcsy-Zsilinszky út 16 H-1368 Budapest, HU
Priority Data:
6159/8924.11.1989HU
Title (EN) NOVEL THIAZOLIDINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME
(FR) NOUVEAUX DERIVES DE THIAZOLIDINONE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR PROCEDE DE PREPARATION
Abstract:
(EN) The present invention relates to novel compounds of general formula (I), wherein R means hydrogen or C1-4alkyl group; and Y stands for cyano, trifluoromethyl, aryloxy or aryl(C1-4alkyl)oxy group. The compounds according to the invention show a gastric acid secretion-inhibiting effect and therefore, they are useful for the treatment of gastric and duodenal ulcers. In addition, they exert a cytoprotective action against gastric laesions induced, e.g. by indomethacin or acid-containing alcohol.
(FR) Nouveaux composés de la formule générale (I), dans laquelle R représente hydrogène ou un groupe alkyle contenant 1 à 4 atomes de carbone; et Y représente cyano, trifluorométhyle, aryloxy ou un groupe aryl(C1-4alkyl)oxy. Les composés de l'invention présentent un effet inhibant la sécrétion d'acide gastrique, et par conséquent ils sont utiles dans le traitement d'ulcères gastriques et duodénaux. De plus, ils exercent une action cytoprotectrice contre les lésions gastriques induites, par exemple, par de l'indométacine ou de l'alcool contenant de l'acide.
Designated States: JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0455774US5169859KR1019920701185BG60536